A5041660822- Cytokine Signaling Pathways and Interactions
- Research on Leishmaniasis Studies
- Protein Kinase Regulation and GTPase Signaling
- T-cell and B-cell Immunology
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Parasites and Host Interactions
- Toxin Mechanisms and Immunotoxins
- Melanoma and MAPK Pathways
- Trypanosoma species research and implications
- Land Use and Ecosystem Services
- Immune cells in cancer
- Remote-Sensing Image Classification
- Phytochemicals and Medicinal Plants
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Parasitic Diseases Research and Treatment
- Galectins and Cancer Biology
- Respiratory and Cough-Related Research
- Vector-borne infectious diseases
- Dermatology and Skin Diseases
- Herbal Medicine Research Studies
- Ear Surgery and Otitis Media
- Remote Sensing in Agriculture
- Bioactive Compounds and Antitumor Agents
George Washington University
2023-2024
National Centre for Cell Science
2015-2023
Institute of Medical Sciences
2023
African cities are growing rapidly and more than half of their populations live in deprived areas. Local stakeholders urgently need accurate, granular, routine maps to plan, upgrade, monitor dynamic neighborhood-level changes. Satellite imagery provides a promising solution for consistent, accurate high-resolution globally. However, most studies use very high spatial resolution images, which often cover only small areas cost prohibitive. Additionally, model transferability new remains...
Abstract Leishmania major is a parasite that resides and replicates in macrophages. We previously showed the enhanced CD40-induced Raf-MEK-ERK signaling but inhibited PI3K-MKK-p38MAPK to proleishmanial effects. As Raf PI3K have Ras-binding domain exert opposite effects on infection, we examined whether Ras isoforms had differential roles infection. observed L. N-Ras H-Ras expression K-Ras infection activity activity. TLR2 short hairpin RNA or anti-TLR2 anti-lipophosphoglycan Abs reversed...
Abstract Background Ras are small cellular GTPases which regulate diverse processes. It has three isoforms: H-Ras, K-Ras, and N-Ras. Owing to the N-terminus (1–165 residues) sequence homology these isoforms were thought be functionally redundant. However, only K-Ras-deficient mice but not H-Ras- N-Ras-deficient show embryonic lethality. Similarly, mutations in a given isoform associated with particular type of cancer. Moreover, we have previously reported that perform unique functions...
Ras, a GTP-GDP binary switch protein, transduces signals from diverse receptors to regulate various signaling networks. Three Ras genes encode for protein isoforms, namely, Harvey (H-Ras), Kirsten (K-Ras, with two splice variants, K-Ras4A and K-Ras4B), Neuroblastoma (N-Ras). The isoforms undergo series of post-translational modifications that enable their membrane attachment biological activity. activation is tightly regulated, any dysregulation affects cellular processes, such as cell...
Tumor progression in host leads to severe impairment of intrathymic T cell differentiation/maturation, leading the paralysis cellular anti-tumor immunity. Such suppression manifests erosion CD4+CD8+ double positive (DP) immature thymocytes and a gradual increase CD4-CD8- negative (DN) early progenitors. Impact such changes on progenitor pool context cancer remains poorly investigated. Here, we show that tumor blocks Lin-Thy1.2+CD25+CD44+c-KitlowDN2b Lin-Thy1.2+CD25+CD44-c-Kit-DN3 transition...
Population living in deprived conditions continues to grow, highlighting the urgent need for accurate high-resolution maps and detailed statistics plan interventions monitor changes. Unfortunately, data on areas or "slums" is often unavailable, incomplete, outdated. Leveraging satellite imagery can offer timely, consistent information over large area However, there are limited studies that use free open source be used map across multiple cities. To address these challenges, this study...
Introduction 
 Aggressive management of chronic suppurative otitis media is necessary as untreated and poorly treated unsafe cases can result in a variety complications. Aim this study was to identify the bacteriological profile determine antibiotic susceptibility pattern aerobic bacterial isolates patients media.
 Materials methods: Observational cross-sectional conducted at outpatient department ENT collaboration with Microbiology from December 2022 March 2023. A calculated...
Abstract IFNγ and IL10 pathways elicit functionally opposing cell fates, however, these two stimuli activate common transcription factors like STAT1 STAT3 (S/1/3). How the regulate dynamics of S/1/3 activation remains less understood. Here, we experimentally measured signaling in response to found that STAT3, particular, exhibits a bell-shaped both with maximal an intermediate dose. We built mathematical model, which quantitatively captured by model analysis, identified primary regulators...