A5067268387- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Invertebrate Immune Response Mechanisms
- Retinal Development and Disorders
- Microtubule and mitosis dynamics
- Immunodeficiency and Autoimmune Disorders
- Animal Virus Infections Studies
- interferon and immune responses
- Plant Molecular Biology Research
- SARS-CoV-2 and COVID-19 Research
- Hippo pathway signaling and YAP/TAZ
- Telemedicine and Telehealth Implementation
- Adenosine and Purinergic Signaling
- Insect symbiosis and bacterial influences
- Monoclonal and Polyclonal Antibodies Research
Institute of Medical Microbiology and Hygiene
2023
Heinrich Heine University Düsseldorf
2008-2022
Düsseldorf University Hospital
2022
Summary The tumour suppressor Lethal (2) giant discs (Lgd) is a regulator of endosomal trafficking the Notch signalling receptor as well other transmembrane proteins in Drosophila. loss its function results an uncontrolled ligand-independent activation receptor. Here, we investigated consequences lgd and requirements for Notch. We show that cells independent Kuz dependent on γ-secretase. found have defect delays degradation proteins, which are residents plasma membrane. Furthermore, our...
The bristle sensillum of the imago Drosophila is made four cells that arise from a sensory organ precursor cell (SOP). This SOP selected within proneural clusters (PNC) through mechanism involves Notch signalling. PNCs are defined expression domains genes, whose activities enables to become SOPs. They encode tissue specific bHLH proteins form functional heterodimers with protein Daughterless (Da). In prevailing lateral inhibition model for selection, transcriptional feedback loop pathway...
Most SARS-CoV-2 proteins are translated from subgenomic RNAs (sgRNAs). While the majority of these sgRNAs monocistronic, some viral mRNAs encode more than one protein. One example is ORF3a sgRNA that also encodes ORF3c, an enigmatic 41-amino-acid peptide. Here, we show ORF3c expressed in SARS-CoV-2-infected cells and suppresses RIG-I- MDA5-mediated IFN-β induction. interacts with signaling adaptor MAVS, induces its C-terminal cleavage, inhibits interaction RIG-I MAVS. The immunosuppressive...
The tumour suppressor gene lethal (2) giant discs (lgd) is involved in endosomal trafficking of transmembrane proteins Drosophila. Loss function results the ligand-independent activation Notch pathway all imaginal disc cells and follicle cells. Analysis lgd loss has largely been restricted to suggests that no other signalling affected. devotion Lgd was puzzling given also affects components pathways, such as Dpp (a Drosophila BMP) pathway. Moreover, physically interacts with Shrub, a...
Background Systemic Lupus Erythematosus (SLE) is an autoimmune disorder characterised by polyclonal Bcell activation, production of dsDNA-autoantibodies and cytokines. Subsets Bcells play a central role in SLE-pathogenesis. The inflammatory milieu the accumulation adenosine, which confers immunosuppressive effects. Objectives In SLE, CD73, enzyme involved extracellular generation adenosine from ATP, not well characterised. This study aimed to characterise expression CD73 subsets SLE-patients...
Background During the COVID-19 pandemic telemedicine tools rapidly and widely gained acceptance as indispensable management for continuum of clinical care in rheumatic diseases. They have been adopted position papers guidelines diseases adult patients. Objectives Evaluation use video consultation one form before during associated lockdowns among Rheumatology physicians Germany. The survey results are expected to support optimization implementation (VC) into routine practice rheumatology,...