A5004712508- Atherosclerosis and Cardiovascular Diseases
- Congenital heart defects research
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- Birth, Development, and Health
Louisiana State University Health Sciences Center Shreveport
2023-2025
Introduction Atherosclerosis is a progressive disease that develops in areas of disturbed flow (d-flow). Progressive atherosclerosis characterized by bulky plaques rich mesenchymal cells and high-grade inflammation can rupture leading to sudden cardiac death or acute myocardial infarction. In response d-flow, endothelial acquire phenotype through endothelial-to-mesenchymal transition (EndMT). However, the signaling intermediaries link d-flow EndMT are incompletely understood. Methods Results...
Background and Objective: Accumulative evidence has demonstrated the phenotypic transition of endothelium to endothelial-to-mesenchymal (EndMT) in human atheroma. Disturbed flow (d-flow) is one main triggers EndMT formation, however, there little on signaling intermediaries that link d-flow formation. Herein, we described a novel role for endothelial interleukin-1 receptor (IL-1R1) d-flow-induced vitro vivo . Methods Results: We found IL-1R1 predominantly expressed coronary stable...