A5057404487- Advanced Radiotherapy Techniques
- Advances in Oncology and Radiotherapy
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Radiation Dose and Imaging
- Pelvic and Acetabular Injuries
- Clinical practice guidelines implementation
- Venous Thromboembolism Diagnosis and Management
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Occupational Health and Performance
- Prostate Cancer Diagnosis and Treatment
- Healthcare Systems and Challenges
- Medical Imaging Techniques and Applications
- Bone health and osteoporosis research
- Mitochondrial Function and Pathology
- Patient Satisfaction in Healthcare
- PARP inhibition in cancer therapy
- Chronic Lymphocytic Leukemia Research
- Lower Extremity Biomechanics and Pathologies
- Vascular Procedures and Complications
- COVID-19 and healthcare impacts
- Diabetes Management and Education
Croydon University Hospital
2024-2025
Cambridge University Hospitals NHS Foundation Trust
2018-2023
Newcastle University
2021-2023
Vanderbilt University
2017
Princess Royal Hospital
2016
Diabetes Canada
2012
Université Paris Cité
2001
AimsRadiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses heart and lung should be minimised. This dosimetry study compared ability three-dimensional conformal arc therapy proton beam (PBT) techniques with without breath-hold achieve volume constraints while minimising dose organs at risk (OARs).Materials methodsIn 14 patients' datasets, seven radiotherapy were...
Implement scripted automatic breast planning (AP) for techniques within Raystation.Manual plans (MPs) were re-planned and compared with AP whole (WB), partial (PB), hybrid volumetric modulated arc therapy simultaneous integrated boost (VMAT SIB) VMAT nodal plans.WB took 7 min comparing well to MP. One WB failed a mandatory dose constraint. Small statistically significant differences showed improved coverage at expense of slightly hotter plans, however absolute small (mean < 1% or D 0.5cc<0.2...
Abstract Background: Activating mutations in PIK3CA, encoding the p110α subunit of phosphatidylinositol 3-kinase (PI3K), are highly prevalent breast cancer and solid tumor malignancies. GDC-0077 is a potent p110α-selective inhibitor with novel mechanism action that degrades mutant anti-tumor activity PIK3CA-mutant xenograft models as single agent combination anti-estrogens or without CDK4/6 inhibitor. An open-label, Phase I dose-escalation study monotherapy combined endocrine therapies...
Abstract Background: Dysregulation of the PI3K/AKT/mTOR signaling pathway occurs in solid tumor malignancies. GDC-0077 (G) is a potent p110α-selective, p110α-mutant degrading inhibitor with anti-tumor activity PIK3CA-mutant breast cancer xenograft models as single agent and combination endocrine therapies (ET) or without CDK4/6 (i). An open-label, Phase I dose escalation study Galone ET P underway patients (pts) locally advanced metastatic tumors. Data from combinations G L pts HR+/HER2- are...
Drs. Hutchinson and Craik are co-presenting joint first authors. <b>Background:</b> British Thoracic Society guidelines state that oxygen should be used to treat hypoxaemia prescribed a target saturation range. <sup>[1]</sup> Patients at risk of type 2 respiratory failure 88-92%, with the rest 94-98%.This audit aims identify current practice in Telford9s Princess Royal Hospital compared BTS National Audit 2013. <sup>[2]</sup> <b>Methods:</b> Target standards: 90% patients receiving have 100%...
Background Inavolisib (GDC-0077) is a PI3Kα-selective inhibitor and mutant-PI3Kα-degrader demonstrating antitumor activity in PIK3Camut-BC xenograft-models. Phase-I/Ib-data of inavolisib + palbo fulvestrant PIK3CAmut, HR+/HER2-neg-mBC are presented (ongoing study; NCT03006172).
<b>Background/Objectives:</b> UK Emergency and Acute Departments are increasingly adopting triage urgent call systems for a wide range of acute respiratory presentations with an over-reliance on the Early Warning Scoring (EWS) systems. The primary objective presently was to re-assess individual components EWS scores in pulmonary thrombo-embolic disease (PTE). <b>Methods:</b> Data from 1700 investigated by Computed Tomography Pulmonary Angiography (CTPA) over 12 month period were analysed...
This research is funded by The Royal Marsden National Institute of Health Research Biomedical Centre grant ‘A079 - HeartSpare-Plus: Optimising radiotherapy planning and delivery for pan-regional lymph node radiotherapy in patients with breast cancer’. Dr Charlotte Coles is supported the Cambridge National Institute Health Research Centre.
Abstract Cytotoxic chemotherapy is the standard of care for patients with triple negative breast cancer (TNBC). Most advanced TNBC progress after and die from metastatic disease. MCL1 an anti-apoptotic Bcl-2 family member known to sequester inactivate pro-apoptotic proteins and, thus, contribute resistance. We previously reported that ~45% residual TNBCs remain in neoadjuvant harbor amplification, suggesting a causal role drug A recent report (Goodwin et al. 2015) suggested siRNA-mediated...
Regional Medical Physics Department, Newcastle General Hospital and Stockton Pharmaceutical Quality Control Laboratory, Stockton, UK
Abstract Background In the UK around 50% of cases pancreatitis are caused by gallstones. BSG guidelines recommend ERCP is undertaken within 72h onset pain and patients should undergo definitive treatment with cholecystectomy if fit enough during index admission or two weeks discharge to avoid risk potentially fatal recurrent pancreatitis. A national audit in 2015 showed that 34.2% receive treatment. During first COVID-19 wave our surgical service was forced modify practice including more...
While I appreciate that the Sister Susie column is written tongue in cheek, it seems to me sad she makes constant jibes at staff who have obtained NVQ certificates.
The article in Nursing Standard entitled 'NVQ for the dole' (Viewpoint, August 24) is yet another example of ostrich-like behaviour by nursing academics.