A5009415712- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Retinal Development and Disorders
- Quantum optics and atomic interactions
- Quantum Information and Cryptography
- Mitochondrial Function and Pathology
- CRISPR and Genetic Engineering
- Dendrimers and Hyperbranched Polymers
- Quantum and electron transport phenomena
- Semiconductor materials and devices
- DNA and Nucleic Acid Chemistry
- International Development and Aid
Trinity College Dublin
2023
University of St Andrews
2023
Missouri University of Science and Technology
2018-2022
Phelps County Regional Medical Center
2018
We demonstrate by use of continuous wave- and pulse-electron paramagnetic resonance spectroscopy on oriented single crystals magnetically dilute YbIII ions in Yb0.01Lu0.99(trensal) that molecular entangled two-qubit systems can be constructed exploiting dipolar interactions between neighboring centers. Furthermore, we show the phase memory time Rabi frequencies these dipolar-interaction-coupled are comparable to ones corresponding qubits.
Previous studies have shown that chemotherapeutic efficacy could be enhanced with targeted drug delivery. Various DNA origami nanostructures been investigated as carriers. Here, we compared delivery functionalities of three similar nanostructures, Disc, Donut, and Sphere, differ in structural dimension. Our results demonstrated Donut was the most stable exhibited highest Dox-loading capacity. MUC1 aptamer modification our increased cellular uptake MUC1-high MCF-7. Among unmodified exerted...
We demonstrate area-selective atomic layer deposition (ALD) of oxides on DNA nanostructures. Area-selective ALD Al2O3, TiO2, and HfO2 was successfully achieved both 2D 3D nanostructures deposited a polystyrene (PS) substrate. The resulting DNA–inorganic hybrid structure used as hard mask to achieve deep etching Si wafer for antireflection applications. is widely process in coating thin film deposition; our work points way pattern oxide materials using templates enhance the chemical/physical...
Age-related macular degeneration (AMD) is the most common cause of blindness in aged population. However, to date there no effective treatment for dry form disease, representing 85–90% cases. AMD an immensely complex disease which affects, amongst others, both retinal pigment epithelium (RPE) and photoreceptor cells leads progressive loss central vision. Mitochondrial dysfunction RPE emerging as a key player disease. There are indications that during progression, first impaired turn...
We present a novel metal-ion stimulated organization of DNA origami nanostructures by employing G-quadruplexes as stimuli-responsive bridges. The reversible assembly process was the result conformational changes between G-quadruplex and its single-strand state induced monovalent cations. This study might stimulate new design responsive DNA-based intelligent nanomaterials.
The hybridization of gold nanoparticles (AuNPs), along with other nanomaterials, has encouraged applications in biomedical imaging, plasmonic enhancement, and catalysts. However, the rational organization AuNPs nanotechnology fields remains difficult, which might require multiaddressability for heterogeneous conjugation. In this work, multifunctional were developed by conjugation two types DNA strands containing different sequences, allowed to recognize multiple binding sites. ratio...