A5089821000- Developmental Biology and Gene Regulation
- Kruppel-like factors research
- Advanced biosensing and bioanalysis techniques
- Angiogenesis and VEGF in Cancer
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Estrogen and related hormone effects
- Cancer-related gene regulation
- Carbon and Quantum Dots Applications
- Hedgehog Signaling Pathway Studies
- Hair Growth and Disorders
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Plasmonic and Surface Plasmon Research
- Cell Adhesion Molecules Research
- Dye analysis and toxicity
- Nanocluster Synthesis and Applications
- Histone Deacetylase Inhibitors Research
- Vascular Malformations and Hemangiomas
- Vascular Tumors and Angiosarcomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Tyrosine Phosphatases
- TGF-β signaling in diseases
- Nanopore and Nanochannel Transport Studies
Mahidol University
2013-2024
Columbia University Irving Medical Center
2010-2015
Columbia University
2005-2013
Lupeol and stigmasterol, major phytosterols in various herbal plants, possess anti-inflammatory activities have been proposed as candidates for anti-cancer agents, but their molecular mechanisms are still unclear. Here, we investigated the effects of lupeol stigmasterol on tumor endothelial cells vitro vivo. Our results demonstrated that suppressed cell viability, migration, morphogenesis human umbilical vein (HUVECs) not cholangiocarcinoma (CCA) cells. Expression analyses showed treatment...
The discovery that Notch, a key regulator of cell fate determination, is functional in the vasculature has greatly improved our understanding differentiation and specialization vessels. Notch signaling been proven to be critical for arterial specification, sprouting angiogenesis, vessel maturation. In newly forming vascular sprouts, promotes distinction between leading "tip" endothelial growing "stalk" cell, cells eventually form new capillary. also implicated stability by regulating mural...
A proangiogenic role for Jagged (JAG)-dependent activation of NOTCH signaling in the endothelium has yet to be described. Using proteins that encoded different NOTCH1 EGF-like repeats, we identified unique regions Delta-like ligand (DLL)-class and JAG-class ligand-receptor interactions, developed decoys function as ligand-specific inhibitors. N110-24 decoy blocked JAG1/JAG2-mediated signaling, angiogenic sprouting vitro, retinal angiogenesis, demonstrating JAG-dependent signal promotes...
We have previously formulated a list of approximately 2,000 RNA octamers as putative exonic splicing enhancers (PESEs) based on statistical comparison human and nonexonic sequences (X. H. Zhang L. A. Chasin, Genes Dev. 18:1241-1250, 2004). When inserted into poorly spliced test exon, all eight tested stimulated splicing, result consistent with their identification (ESEs). Here we present much more stringent the validity this PESEs. Twenty-two naturally occurring examples nonoverlapping PESEs...
Abstract The Notch pathway plays multiple key roles in tumorigenesis, and its signaling components have therefore aroused great interest as targets for emerging therapies. Here, we show that inhibition of Notch, using a soluble receptor Notch1 decoy, unexpectedly caused remarkable increase liver metastases from neuroblastoma breast cancer cells. Increased were also seen after treatment with the γ-secretase inhibitor PF-03084014. Transgenic mice heterozygous loss demonstrated marked hepatic...
Previous studies have shown that chemotherapeutic efficacy could be enhanced with targeted drug delivery. Various DNA origami nanostructures been investigated as carriers. Here, we compared delivery functionalities of three similar nanostructures, Disc, Donut, and Sphere, differ in structural dimension. Our results demonstrated Donut was the most stable exhibited highest Dox-loading capacity. MUC1 aptamer modification our increased cellular uptake MUC1-high MCF-7. Among unmodified exerted...
Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Southeast Asia, but effective treatment options remain limited, and chemotherapy has high resistance rate. Asiatic acid (AA), triterpenoid found Centella asiatica, shown anticancer activity various cancers. Therefore, this study aims to investigate the effects mechanisms of AA NPC cell lines. The on cytotoxicity, apoptosis, migration were determined TW-01 SUNE5-8F Western blot analysis was performed evaluate protein expression levels...
Anti-angiogenesis is a validated strategy to treat cancer, with efficacy in controlling both primary tumor growth and metastasis. The role of the Notch family proteins angiogenesis still emerging, but recent data suggest that signaling may function physiologic response loss VEGF signaling, thus participate adaptation inhibitors.We asked whether combining blockade would enhance suppression growth, using NGP neuroblastoma model. tumors were engineered express Notch1 decoy construct, which...
Infantile hemangioma (IH) is a vascular tumor that begins with rapid proliferation shortly after birth, followed by involution in early childhood. We have found NOTCH3, critical regulator of mural cell differentiation and maturation, expressed stem cells (HemSCs), suggesting NOTCH3 may function HemSC-to-mural pathological vessel stabilization. Here, we demonstrate NG2+PDGFRβ+ perivascular HemSCs CD31+GLUT1+ endothelial (HemECs) proliferating IHs becomes mostly restricted to the...
Abstract Carbon dots (CDs) are fascinating nanomaterials with technologically relevant properties; however, the effects of heteroatom doping on several properties CDs have not been studied. In this work, a facile method for synthesis and carbon from table sugar was developed using nitric acid, phosphoric sulfuric acid as simultaneous catalysts dopants. The optical properties, phenolic content, antioxidant activity, photostability, cytotoxicity were measured compared. L‐ascorbic well‐known...
Vasculogenic mimicry (VM) is the process where cancer cells adopt endothelial characteristics by forming tube-like structures and perfusing channels. This phenomenon has been demonstrated in several types of solid tumors associated with growth survival tumor cells. In this study, we investigated presence VM formation human pancreatic ductal adenocarcinoma (PDAC) elucidated molecular mechanisms underlying process. PDAC tissues, CD31-negative, periodic acid-Schiff (PAS)-positive channels were...
Disturbances in cholesterol homeostasis of the bile duct epithelium, including transport interruption and hyperaccumulation intracellular can lead to initiation progression cholangiocarcinoma (CCA). Statins, which are lipid‑lowering drugs, have been previously documented exhibit anti‑cancer properties. The role statins CCA cell through expression function ATP‑binding cassette (ABC) A1 ABCG1 was investigated current study. In four lines, ABCA1 identified. However, neither ABCG5 nor ABCG8...