A5045007851- Muscle Physiology and Disorders
- Cancer Mechanisms and Therapy
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Seaweed-derived Bioactive Compounds
- Effects and risks of endocrine disrupting chemicals
- Pharmacological Effects of Natural Compounds
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sirtuins and Resveratrol in Medicine
- Curcumin's Biomedical Applications
- Cancer-related gene regulation
- Medicinal Plants and Bioactive Compounds
- Natural Antidiabetic Agents Studies
- Bone Metabolism and Diseases
- biodegradable polymer synthesis and properties
- Tannin, Tannase and Anticancer Activities
Kasetsart University
2022-2025
Siam University
2021
Diabetes-related osteoporosis has been known to be a consequence of oxidative stress caused by excessive reactive oxygen species (ROS) production in the tissues. Despite increase number individuals with diabetes-related year on year, there is still no effective drug that does not induce adverse side effects. Glabridin, which exerts hypoglycemic effects and possesses antioxidant properties, may have beneficial treatment osteoporosis. In this study, we aimed investigate preventive glabridin...
Previous studies showed that bisphenol-A (BPA), a monomer of polycarbonate plastic, is leached out and contaminated in foods beverages. This study aimed to investigate the effects BPA on myogenesis adult muscle stem cells. C2C12 myoblasts were treated with both proliferation differentiation conditions. Cytotoxicity, cell differentiation, antioxidant activity, apoptosis, myogenic regulatory factors (MRFs) gene expression, mechanism examined. exposed 25–50 µM abnormal morphology, expressing...
Diabetes is characterized by high blood glucose level termed hyperglycemia affecting skeletal muscle structure and function an unclear molecular mechanism.This study aimed to investigate the effect underlying mechanism(s) of on both in vitro vivo.Treatment with hyperglycemic condition (25 mM) for 48 h significantly inhibited C2C12 myoblast proliferation detected MTT assay whilst flow cytometry revealed interruption cell cycle at subG1 G2/M phases.An exposure decreased myosin heavy chain...
Sulfated galactans (SG) isolated from red alga Gracilaria fisheri have been reported to inhibit the growth of cholangiocarcinoma (CCA) cells, which was similar epidermal factor receptor (EGFR)-targeted drug, cetuximab. Herein, we studied anti-cancer potency SG compared Biological studies demonstrated and cetuximab had inhibition mechanisms in CCA cells by down-regulating EGFR/ERK pathway, combined treatment induced a greater effect. The molecular docking study revealed that binds...
Purpose: To evaluate the toxicity of dried seaweed, Sargassum plagiophyllum, extract (SPE) pretreatment in constipated mice.Methods: The seaweed powder was mixed with distilled water and extracted by autoclave at 121°C. Antioxidant activity determined 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Human normal colon cells were pretreated SPE 0 - 100 μg/mL for 24 h before challenging them μM hydrogen peroxide (H2O2). Intracellular reactive oxygen species (ROS) quantified using 2',7'-...