A5004585736- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Toxin Mechanisms and Immunotoxins
- Ziziphus Jujuba Studies and Applications
- Crystallography and molecular interactions
- Transgenic Plants and Applications
- Biochemical and Structural Characterization
- Phytoplasmas and Hemiptera pathogens
- Cannabis and Cannabinoid Research
- Phytochemistry and Bioactive Compounds
- Plant Stress Responses and Tolerance
- Immune Cell Function and Interaction
- Pharmacological Effects of Natural Compounds
- Traditional and Medicinal Uses of Annonaceae
- Hepatitis B Virus Studies
- Plant tissue culture and regeneration
- Plant Growth Enhancement Techniques
- Flavonoids in Medical Research
- Powdery Mildew Fungal Diseases
- Ginseng Biological Effects and Applications
- Occupational and environmental lung diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Bamboo properties and applications
Banaras Hindu University
1986-2024
University of Freiburg
2019-2023
University Medical Center Freiburg
2021
University of Madras
2003-2009
Institute of Medical Sciences
1986-1988
King Saud University
1987
Indian Institute of Technology BHU
1986
The cyclotide T20K inhibits the proliferation of human immune cells and is currently in clinical trials for multiple sclerosis. Here, we provide novel functional data mechanistic insights into structure–activity relationships T20K. Analogs with partial or complete reduction cystine knot had loss function experiments. Similarly, an acyclic analog was inactive lymphocyte bioassays. lack activity non-native peptide analogs appears to be associated ability cyclotides interact penetrate cell...
Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone six conserved cysteine residues linked by disulfide bonds. Their presence the Violaceae species seems ubiquitous, yet not all members other produce these macrocyclic peptides. The genus
Some plants used in Traditional Chinese Medicine serve as treatment for disease states where a suppression of the cellular immune response is desired. However, compounds responsible immunosuppressant effects these are not necessarily known. The roots Scutellaria baicalensis, one most promising identified previous screening, were tracked by HPLC activity profiling and concomitant on-line spectroscopic analysis. Compounds then isolated preparative chromatography, structures elucidated methods....
Leaf pigments play a crucial role in photosynthesis and protection, which drives plant growth. Rhizospheric bacteria playing pivotal promoting development, also affects leaf pigmentation. The present study was therefore aimed to assess the influence of growth-promoting rhizobacterial (PGPR) treatments on growth at early stages Brassica juncea (L.). Pot experiments were conducted with selected rhizobacteria for 2 months. Although responses varied among different PGPR inoculants, Pseudomonas...
Viscum album L. (VA) preparations possess immunomodulatory properties and are used in complementary medicine to support cancer therapy. It is unclear if there an impact of VA on the expression immune checkpoint proteins surface cells. This study was designed investigate role commercially available programmed death ligand 1, 2 (PD-L1, PD-L2) major histocompatibility complex class I (MHC-I).Four human cell lines (prostate, colon, lung, breast) were assayed for their PD-L1, PD-L2, MHC-I level...
A new diterpene, viz. 3β-acetoxy-4α,18:15,16-diepoxy-6β,12-dihydroxyneocleroda-13(16),14-dien-19,20-olide, C22H28O8, exhibiting antifeedant activity against Spodoptera litura was isolated from the aerial parts of Teucrium tomentosum and its structure is reported. One two fused rings has a distorted-chair conformation other chair conformation. The molecules in crystal are stabilized via O—H⋯O C—H⋯O hydrogen bonds.
A neo-clerodane diterpene, 15-hydroxy-15,16-epoxy-6α-neo-cleroda-3,13(16),14-triene-18,19:20,12-diolide, C20H22O6, showing antifeedant activity against lepidopterous pests, has been isolated from Teucrium tomentosum and characterized by NMR X-ray crystallographic methods. The studies reveal that the cyclohexene cyclohexane rings adopt a half-chair chair conformation, respectively. furan ring exhibits rotational disorder. molecules in crystal structure are stabilized network of O—H⋯O C—H⋯O...
The title compound (systematic name: 7-furan-3-yl-6-hydroxy-4,4,8,10,13-pentamethyl-1,8,9,10,11,12,13,15,16,17-decahydro-2H,4H-20-oxacyclopropa[14,15]cyclopenta[a]phenanthrene-3,7-dione), C26H32O5, is a semi-synthetic derivative of cedrelone, natural isolated from Toona ciliata. orientation the furan ring and conformations are same as for cedrelone itself, with exception A. Rings A, B, C D adopt sofa, half-chair, twist envelope conformations, respectively. crystal structure involves...
Abstract For see ChemInform in Full Text.
The title compound (systematic name: 24-nor-13α,14β,15β,17α-chola-1,5,20-triene-14,15:21,23-diepoxy-6-hydroxy-4,4,8-trimethyl-3,7,21-trione), C26H30O6, is a semisynthetic derivative of cedrelone, obtained via microwave oxidation. Modification the parent results in change orientation furan ring; however, conformations other rings are not altered. adopted by A–E boat, half-chair, twist, envelope and planar, respectively. Motifs R22[10], S(5), C(7) C(12) formed through O—H⋯O C—H⋯O hydrogen...
The title compound (systematic name: 17-furan-3-yl-6,15-dihydroxy-4,4,8,10,14-pentamethyl-8,9,10,11,12,14,15,16-octahydro-4H-cyclopenta[a]phenanthrene-3,7-dione), C26H30O5, is a semi-synthetic derivative of cedrelone, tetranortriterpenoid isolated from Toona ciliata. Both cedrelone and the show similar antifeedant activity against third instar larvae Spodoptera litura. modification D ring parent has altered conformation C; however, orientation furan as well conformations other rings...
The title compound, C20H30O6, is a semisynthetic derivative of diterpene, 3-epicaryoptin, isolated from Clerodendron calamitosum. two fused cyclohexane rings adopt chair conformations and the five-membered an envelope planar conformation. O atoms hydroxy groups participate in hydrogen bonding R21(6) R22(4) ring motifs are formed crystal structure.