A5053817909- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- stochastic dynamics and bifurcation
- Neuroscience and Neuropharmacology Research
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Neural Networks and Applications
- EEG and Brain-Computer Interfaces
- Neurobiology and Insect Physiology Research
- Visual perception and processing mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Retinal Development and Disorders
- Pancreatic function and diabetes
- Lipid Membrane Structure and Behavior
- CCD and CMOS Imaging Sensors
- Metabolism, Diabetes, and Cancer
- Muscle activation and electromyography studies
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Physiological and biochemical adaptations
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Conducting polymers and applications
- Supramolecular Self-Assembly in Materials
- Microfluidic and Bio-sensing Technologies
Lithuanian University of Health Sciences
2006-2022
Kaunas University of Technology
2000-2010
New York University
2000-2010
Vilnius University
2006-2010
RELX Group (United Kingdom)
2005
University of Copenhagen
1997-2003
Courant Institute of Mathematical Sciences
2000
Vytautas Magnus University
1997
Biomedical Research Institute
1997
Svirskis, Gytis and Jørn Hounsgaard. Transmitter regulation of plateau properties in turtle motoneurons. J. Neurophysiol. 79: 45–50, 1998. In motoneurons, generation potentials is promoted by modulators that block potassium channels. voltage-clamp experiments with triangular voltage ramp commands, we show cis-(±)-1-aminocyclopentane-1,3-dicarboxylic acid ( cis-ACPD) muscarine promote the increasing dihydropyridine sensitive inward current, input resistance, depolarizing resting membrane...
Neurons possess multiple voltage-dependent conductances specific for their function. To investigate how low-threshold outward currents improve the detection of small signals in a noisy background, we recorded from gerbil medial superior olivary (MSO) neurons <i>in vitro</i>. MSO responded phasically, with single spike to step current injection. When bathed dendrotoxin (DTX), most cells switched tonic firing, suggesting that potassium (<i>I</i><sub>KLT</sub>) participated shaping these phasic...
Voltage-dependent membrane conductances support specific neurophysiological properties. To investigate the mechanisms of coincidence detection, we activated gerbil medial superior olivary (MSO) neurons with dynamic current-clamp stimuli in vitro. Spike-triggered reverse-correlation analysis for injected current was used to evaluate integration subthreshold noisy signals. Consistent previous reports, partial blockade low-threshold potassium channels (I(KLT)) reduced detection by slowing rise...
Plasticity at the neuronal level commonly involves use-dependent changes in strength of particular synaptic pathways or regulation postsynaptic properties by modulatory transmitters. Here we analyze a novel form short-term plasticity mediated facilitation responsiveness. Using current- and voltage-clamp recordings, found that all spinal ventral horn neurons able to generate plateau potentials showed depolarization-induced underlying inward current. Facilitation was noticeable when were...
The effect of a brief train electric stimuli in the dorsolateral funiculus on intrinsic response properties turtle motoneurones was investigated transverse sections spinal cord vitro. Even when glutamatergic, GABAergic and glycinergic ionotropic synaptic transmission blocked by antagonists AMPA, NMDA, glycine GABA receptors, (DLF) stimulation induced facilitation plateau potentials during current clamp underlying inward voltage clamp. This lasted more than 10 s. potential DLF absent presence...
Low-frequency sound localization depends on the neural computation of interaural time differences (ITD) and relies neurons in auditory brain stem that integrate synaptic inputs delivered by ipsi- contralateral pathways start at two ears. The first respond selectively to ITD are found medial superior olivary nucleus (MSO). We identified a new mechanism for coding using slice preparation preserves binaural MSO. There was an internal latency difference excitatory would, if left uncompensated,...
Brief synaptic inhibition can overwhelm a nearly coincident suprathreshold excitatory input to preclude spike generation. Surprisingly, brief inhibitory event that occurs in favorable time window preceding an otherwise subthreshold excitation facilitate spiking. Such postinhibitory facilitation (PIF) requires the has short (decay) constant tauinh. The timescale ranges of tauinh and (width timing) for PIF depend on rates neuronal dynamics. mechanism is general, involving reduction by...
Hydrogel-supported neural cell cultures are more in vivo-relevant compared to monolayers formed on glass or plastic substrates. However, there is a lack of synthetic microenvironment available for obtaining standardized and easily reproducible characterized by tissue-mimicking composition, cell-cell interactions, functional networks. Synthetic peptides representing the biological properties extracellular matrix (ECM) proteins have been reported promote adhesion-driven differentiation...
Understanding how voltage-regulated channels and synaptic membrane conductances contribute to response properties of neurons requires reliable knowledge the electrotonic structure dendritic trees. A novel method based on weak DC field stimulation classical current injection were used obtain two independent estimates motoneurons in an vitro preparation turtle spinal cord. was also ensure that passive near resting potential homogeneous. In cells, difference lengths estimated with methods same...
Svirskis, Gytis, Aron Gutman, and Jørn Hounsgaard. Detection of a membrane shunt by DC field polarization during intracellular whole cell recording. J. Neurophysiol. 77: 579–586, 1997. Lower input resistance with recording, rather than usually has been ascribed to produced penetration injury. An alternative explanation is higher recording due wash-out cytoplasmatic substances. We have used neuronal at the onset termination an applied electric for detection. analytical expression was derived...
Subthreshold voltage- and time-dependent conductances can subserve different roles in signal integration action potential generation. Here, we use minimal models to demonstrate how a non-inactivating low-threshold outward current (I(KLT)) enhance the precision of small-signal integration. Our integrate-and-fire have only few biophysical parameters, enabling parametric study I(KLT) effects. increases signal-to-noise ratio (SNR) for firing when subthreshold 'signal' EPSP is delivered presence...
Subthreshold voltage- and time-dependent conductances can subserve different roles in signal integration action potential generation. Here, we use minimal models to demonstrate how a non-inactivating low-threshold outward current (IKLT) enhance the precision of small-signal integration. Our integrate-and-fire have only few biophysical parameters, enabling parametric study IKLT's effects. IKLTincreases signal-to-noise ratio (SNR) for firing when subthreshold 'signal' EPSP is delivered...
Neuronal-glial cell cultures are usually grown attached to or encapsulated in an adhesive environment as evenly distributed networks lacking tissue-like density, organization and morphology. In such cultures, microglia have activated amoeboid morphology do not display extended intensively branched processes characteristic of the ramified tissue microglia. We recently described self-assembling functional cerebellar organoids promoted by hydrogels containing collagen-like peptides (CLPs)...
In the brain spike synchronization in neurons is involved information transfer and certain forms of dysfunction. The theory random point processes was used to relate statistical properties input between firing viewed as threshold devices. Derived analytical relations describe normalized case shared with balanced excitation inhibition. For neuronal models unbalanced generating Hodgkin-Huxley type conductances, satisfactorily describes temporal dependence on delay spikes. Computer generated...
In the superior colliculus, visual stimuli can induce gamma frequency oscillations of neuronal activity. It has been shown that in cats, these are synchronized over distances greater than 300 μm may contribute toward information processing. We investigated spatial properties such a rodent because availability molecular tools could enable future studies on role Using extracellular electrode array recordings anesthetized rats, we found stimuli-induced and eta (30–115 Hz) local field potential...