A5074975091- Antifungal resistance and susceptibility
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial Natural Products and Biosynthesis
- Fungal and yeast genetics research
- Fungal Infections and Studies
- Synthesis and Biological Evaluation
- Asthma and respiratory diseases
- Infectious Diseases and Mycology
- Bioinformatics and Genomic Networks
- Mycotoxins in Agriculture and Food
- Aquaculture disease management and microbiota
- Probiotics and Fermented Foods
- Fungal Biology and Applications
University of Wisconsin–Madison
2023-2025
Hyphal growth is essential for host colonization during Aspergillus infection. The transcription factor ZfpA regulates A. fumigatus hyphal development including branching, septation, and cell wall composition. However, how affects fungal susceptibility to immunity infection has not been investigated. Here, we use the larval zebrafish-Aspergillus model primary human neutrophils probe pathogenesis response antifungal drugs in vivo. deletion promotes clearance attenuates virulence wild-type...
ABSTRACT Development of the fungal pathogen Aspergillus flavus involves balance asexual spores (conidia) and overwintering hardened hyphal masses (sclerotia). This is achieved by an oxylipin‐based density‐dependent mechanism regulating switch from sclerotia to conidia as population density increases in A. . Here, we show transcription factor ZfpA, required for normal oxylipin synthesis, regulates morphology switch. ZfpA overexpression (OE:: zfpA ) accelerates shift leading increased conidial...
Abstract Aspergillus fumigatus is the leading causative agent of life-threatening invasive aspergillosis in immunocompromised individuals. One antifungal class used to treat infections fungistatic echinocandins, semisynthetic drugs derived from naturally occurring fungal lipopeptides. By inhibiting beta-1,3-glucan synthesis, echinocandins cause both stunting hyphal growth and repeated fungicidal lysis apical tip compartments. Here, we uncover an endogenous mechanism echinocandin tolerance A....
Background Aspergillus fumigatus is a well-known opportunistic pathogen that causes range of diseases including the often-fatal disease, invasive pulmonary aspergillosis (IPA), in immunocompromised populations. The severity IPA dependent on both host- and pathogen-derived signaling molecules mediate host immunity fungal growth. Oxylipins are bioactive oxygenated fatty acids known to influence immune response developmental programs. synthesizes 8-HODE 5,8-diHODE have structural similarities...
ABSTRACT Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful, sometimes lethal, diseases known as aspergilloses. Understanding the gene regulatory networks that specify expression programs underlying this fungus’ diverse phenotypes can shed mechanistic insight into its growth, development, and determinants of pathogenicity. We used eighteen RNA-seq datasets (seventeen publicly available one previously unpublished) to construct comprehensive network...
can cause invasive pulmonary aspergillosis (IPA). Fungicidal azoles and fungistatic caspofungin (CAS) are the first- second-line therapies, respectively, used to treat IPA. Treatment of
Abstract Hyphal growth is essential for host colonization during Aspergillus infection. The transcription factor ZfpA regulates A. fumigatus hyphal development including branching, septation, and cell wall composition. However, how affects fungal susceptibility to immunity infection has not been investigated. Here, we use the larval zebrafish- model primary human neutrophils probe pathogenesis response antifungal drugs in vivo . deletion promotes clearance attenuates virulence wild-type...