A5036179944- Microbial Natural Products and Biosynthesis
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Plant-Microbe Interactions and Immunity
- Fungal Biology and Applications
- Bacterial biofilms and quorum sensing
- Phytochemical compounds biological activities
- Fungal and yeast genetics research
- Probiotics and Fermented Foods
- Mycotoxins in Agriculture and Food
- Plant Disease Resistance and Genetics
- Insect Pest Control Strategies
- Plant biochemistry and biosynthesis
- Ubiquitin and proteasome pathways
- Insect Resistance and Genetics
- Fungal Infections and Studies
- Insect Utilization and Effects
- Pineapple and bromelain studies
- Peptidase Inhibition and Analysis
- Microbial Metabolism and Applications
- Enzyme Production and Characterization
- Autophagy in Disease and Therapy
- Plant tissue culture and regeneration
- Sirtuins and Resveratrol in Medicine
- Antimicrobial Peptides and Activities
Universidade Estadual de Campinas (UNICAMP)
2019-2025
Abstract Specialized or secondary metabolites are small molecules of biological origin, often showing potent activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis these natural products is governed by sets co-regulated physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs a standardized machine-readable way, Minimum Information Biosynthetic Gene cluster (MIBiG) data standard repository was initiated...
ABSTRACT The human pathogenic fungus Aspergillus fumigatus establishes dual biofilm interactions in the lungs with bacterium Pseudomonas aeruginosa . Screening of 21 A null mutants revealed seven (two G protein-coupled receptors, three mitogen-activated protein kinase a Gα protein, and one histidine receptor) reduced formation, specifically presence P. Transcriptional profiling metabolomics analysis secondary metabolites produced by these mutants, Δ gpaB ( encodes protein), showed GpaB...
Invasive Pulmonary Aspergillosis, which is caused by the filamentous fungus Aspergillus fumigatus , a life-threatening infection for immunosuppressed patients. Chromatin structure regulation important genome stability maintenance and has potential to drive rearrangements affect virulence pathogenesis of pathogens. Here, we performed first A . global chromatin profiling two histone modifications, H3K4me3 H3K9me3, focusing on most investigated clinical isolates, Af293 CEA17. In eukaryotes,...
The interaction between Pseudomonas aeruginosa and Aspergillus fumigatus has been well characterized in vitro . In this scenario, the bacterium exerts a strong inhibitory effect against fungus.
Abstract Aspergillus fumigatus represents a public health problem due to the high mortality rate in immunosuppressed patients and emergence of antifungal-resistant isolates. Protein acetylation is crucial post-translational modification that controls gene expression biological processes. The strategic manipulation enzymes involved protein has emerged as promising therapeutic approach for addressing fungal infections. Sirtuins, NAD + -dependent lysine deacetylases, regulate eukaryotes....
Most of the biosynthetic gene clusters (BGCs) found in microbes are silent under standard laboratory cultivation conditions due to lack expression triggering stimuli, representing a considerable drawback drug discovery. To access full potential, studies towards activation cryptic BGCs essential. Histone acetylation status is an important regulator chromatin structure, which impacts cell physiology and BGCs. In this study, clr3, encoding histone deacetylase Penicillium brasilianum LaBioMMi...
ABSTRACT Most of the biosynthetic gene clusters (BGCs) found in filamentous fungi are silent under standard laboratory cultivation conditions due to lack expression triggering stimuli, representing a considerable drawback drug discovery. To access full potential these microbes, studies towards activation cryptic BGCs essential. Histone acetylation status is an important regulator chromatin structure which impacts cell physiology and, therefore, fungi. deacetylases (HDACs) and histone...
Protein acetylation is a crucial post-translational modification that controls gene expression and variety of biological processes. Sirtuins, prominent class NAD + -dependent lysine deacetylases, serve as key regulators protein in eukaryotes. In this study, six single knockout strains fungal pathogen Aspergillus fumigatus were constructed, addition to strain lacking all predicted sirtuins (SIRTKO). Phenotypic assays suggest are involved cell wall integrity, secondary metabolite production,...
can cause invasive pulmonary aspergillosis (IPA). Fungicidal azoles and fungistatic caspofungin (CAS) are the first- second-line therapies, respectively, used to treat IPA. Treatment of
Abstract In Cystic Fibrosis (CF), mucus plaques are formed in the patient’s lung, creating a hypoxic condition and propitious environment for colonization persistence of many microorganisms. There is clinical evidence showing that Aspergillus fumigatus can co-colonize CF patients with Pseudomonas aeruginosa , which has been associated lung function decline. P. produces several compounds inhibitory anti-biofilm effects against A. vitro; however, little known about fungal produced...
Os microorganismos são as principais fontes de moléculas biologicamente ativas e terapeuticamente úteis, incluindo anticancerígenos, imunossupressores, antibióticos, inseticidas, etc. A biossíntese dos produtos naturais fúngicos é regulada por clusteres gênicos, que se encontram silenciados em condições cultivo padrão laboratório. Para induzir a expressão destes genes, pode-se utilizar engenharia genética. Este trabalho visa manipulação genética modificadores estrutura da cromatina, uma vez...
Abstract Invasive Pulmonary aspergillosis is a life-threatening infection in immunosuppressed patients caused by the filamentous fungus Aspergillus fumigatus . Chromatin structure regulation important for genome stability maintenance and has potential to lead rearrangements driving differences virulence pathogenesis of different A. isolates. Here, we compared chromatin activities most investigated clinical isolates Af293 CEA17 uncovered striking number, locations expression transposable...