Weiming Shen

ORCID: 0009-0009-1158-7613
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About
Contact & Profiles
Research Areas
  • Nanowire Synthesis and Applications
  • Food Quality and Safety Studies
  • Viral Infectious Diseases and Gene Expression in Insects
  • Phytochemical compounds biological activities
  • Tannin, Tannase and Anticancer Activities
  • CAR-T cell therapy research
  • Natural product bioactivities and synthesis

Shanghai Cancer Institute
2025

Renji Hospital
2025

Shanghai Jiao Tong University
2025

Shanghai Sixth People's Hospital
2007-2008

Chimeric antigen receptor (CAR)–T cell therapies have revolutionized the landscape of cancer treatment, in particular context hematologic malignancies. However, for solid tumors that lack tumor-specific antigens, CAR-T cells can infiltrate and attack nonmalignant tissues expressing CAR target antigen, leading to on-target, off-tumor toxicity. Severe toxicities been observed clinical trials therapy tumors, highlighting need address this issue. Here, we demonstrated targeting adhesion...

10.1126/scitranslmed.adl6432 article EN Science Translational Medicine 2025-01-22
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