A5084214274- Microbial metabolism and enzyme function
- Genomics and Phylogenetic Studies
- Hippo pathway signaling and YAP/TAZ
- Microbial Metabolic Engineering and Bioproduction
- Bacterial Genetics and Biotechnology
- Cell Adhesion Molecules Research
- Biochemical Acid Research Studies
- Diet, Metabolism, and Disease
- Antibiotic Resistance in Bacteria
- Biofuel production and bioconversion
- Fermentation and Sensory Analysis
- Epigenetics and DNA Methylation
- Cellular Mechanics and Interactions
- Cellular transport and secretion
- Sugarcane Cultivation and Processing
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Amino Acid Enzymes and Metabolism
- Plant nutrient uptake and metabolism
Inserm
1987-2024
Centre National de la Recherche Scientifique
2022
Université de Montpellier
2022
Institut Pasteur
1987-1989
Tumor recurrence is often attributed to cancer stem cells (CSCs). We previously demonstrated that down-regulation of Pregnane X Receptor (PXR) decreases the chemoresistance CSCs and prevents colorectal recurrence. Currently, no PXR inhibitor usable in clinic. Here, we identify miR-148a as a targetable element upstream signaling CSCs, which when over-expressed expression impairs tumor relapse after chemotherapy mouse xenografts. then develop fluorescent reporter screen for activators...
Tests allowing the screening of large numbers enterobacterial strains for presence glucose oxidation pathway (glucose, gluconate, and 2-ketogluconate dehydrogenases) were devised or adapted. A total 506 representing 111 taxa (named species subspecies unnamed genomic groups) studied. The members genera Budvicia, Edwardsiella, Leminorella, Providencia, Xenorhabdus Citrobacter freundii, Erwinia carnegeana, carotovora, chrysanthemi, nigrifiuens, Salicis, Moellerella wisconsensis, Proteus...
In Xanthomonas campestris pv. campestris, fructose is transported and phosphorylated into 1-phosphate through a phosphoenolpyruvate-dependent phosphotransferase system. The nucleotide sequence of the fruA gene encoding system permease specific (EIIFru) was determined. produced by 1,6-bisphosphate 1-phosphofructokinase. This enzyme characterized corresponding (fruK) sequenced. Sequence comparisons revealed that FruK member new family ATP-binding proteins composed sugar (or sugar-phosphate)...
Abstract Extracellular matrix (ECM) stiffening, resulting from increased collagen deposition and cross-linking, is a key biophysical factor of the tumor microenvironment. Cutaneous melanoma deadly metastatic cancer. Its aggressiveness stems high intratumoral heterogeneity, plasticity cells, which transit melanocytic state to dedifferentiated therapy-resistant invasive phenotypes, characterized by mesenchymal and/or neural crest stem cell-like features. Phenotypic regulated stroma-derived...