A5103101126- Animal Genetics and Reproduction
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Histone Deacetylase Inhibitors Research
- CRISPR and Genetic Engineering
- Protein Degradation and Inhibitors
- Pluripotent Stem Cells Research
- Connexins and lens biology
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Protein Kinase Regulation and GTPase Signaling
- Ophthalmology and Visual Impairment Studies
- PI3K/AKT/mTOR signaling in cancer
- Biological Activity of Diterpenoids and Biflavonoids
- MicroRNA in disease regulation
- Bone health and treatments
- Acupuncture Treatment Research Studies
- Zebrafish Biomedical Research Applications
- Ocular Disorders and Treatments
- Epigenetics and DNA Methylation
- Osteoarthritis Treatment and Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Signaling Pathways in Disease
- Prenatal Screening and Diagnostics
- Nutrition, Genetics, and Disease
Zhejiang University-University of Edinburgh Institute
2023-2024
First Hospital of Jiaxing
2022
Jiaxing University
2022
Harbin Medical University
2020-2021
Lanzhou University
2020
Lanzhou University Second Hospital
2020
Affiliated Hospital of Nantong University
2013
Nantong University
2013
DNA damage is critical in the pathogenesis of age-related cataract (ARC). This study examined association copy number variations (CNVs) repair genes with susceptibility to ARC Han Chinese.Study participants were from population-based Jiangsu Eye Study, which includes 780 patients and 525 controls. was extracted blood for (CN) assays using RT-PCR. The Comet assay assess peripheral lymphocytes.Novel CNV detected WRN. Initial analyses found that CN = 3+ WRN had an increased risk (odds ratio...
The aim was to identify the factors affecting synonymous codon usage bias in newly discovered gC gene of duck plague virus (DPV) CHv strain and a comparative analysis genes 27 other reference herpesviruses performed by using CAI, CHIPS CUSP program EMBOSS. results showed that base composition, mutational and natural selection were major determinants variation DPV gene. primary trends obvious difference with strong towards codons A T at third position. Characterization nucleotide composition...
Hepatocellular carcinoma (HCC) ranks third on the list of leading cause for cancer death globally. The treatment HCC patients is unsatisfactory. However, traditional Chinese medicine Chebulae Fructus has potential efficacy in HCC.We mined active ingredients and its main targets from Traditional Medicine Systems Pharmacology database. HCC-related datasets were downloaded Cancer Genome Atlas database differentially expressed genes (DEGs) obtained by differential expression analysis. Top10...
Abstract Primordial germ cells (PGCs) are the precursors of germline that specified at embryonic stage. Recent studies reveal humans employ different mechanisms for PGC specification compared with model organisms such as mice. Moreover, specific regulatory machinery is still largely unexplored, mainly due to inaccessible nature this complex biological process. Here, we collect and integrate multi-omics data, including 581 RNA-seq, 54 ATAC-seq, 45 ChIP-seq, 69 single-cell RNA-seq samples from...
SUMMARY Processing bodies (P-bodies) are the membraneless organelles that play critical roles in RNA storage and decay. Abnormalities P-bodies contribute to diseases developmental disorders. Huge efforts have been applied identification of protein components P-bodies, however, dynamics human embryonic stem cells (hESCs) during maintenance differentiation remain largely elusive. Here, we characterized profiles from HEK293T cells, hESCs, hESC-derived mesodermal cells. The number decreases upon...