A5103035290- Neuroscience and Neural Engineering
- Cutaneous Melanoma Detection and Management
- EEG and Brain-Computer Interfaces
- Lung Cancer Treatments and Mutations
- Radiation Detection and Scintillator Technologies
- Cancer Genomics and Diagnostics
- Advanced Semiconductor Detectors and Materials
- Infrared Target Detection Methodologies
- Advanced Memory and Neural Computing
- Nonmelanoma Skin Cancer Studies
- Neutrino Physics Research
- CCD and CMOS Imaging Sensors
- Muscle activation and electromyography studies
- Lung Cancer Research Studies
- Advanced Graph Neural Networks
- Particle physics theoretical and experimental studies
- Machine Learning in Materials Science
- Optical Systems and Laser Technology
- Face and Expression Recognition
- Atomic and Subatomic Physics Research
- Advanced optical system design
- Photonic and Optical Devices
- Pancreatic and Hepatic Oncology Research
- Computational Drug Discovery Methods
- Melanoma and MAPK Pathways
University of Utah
2008-2024
Cardiff University
2024
University of Massachusetts Amherst
2024
C4 Imaging (United States)
2021
University of Washington
2021
South Carolina Oncology Associates
2020
Harvard University Press
2020
Applied Research Associates (United States)
2019-2020
Florida Atlantic University
2019
US Biologic (United States)
2018
In Brief Objective and Background: Morbidity, mortality, length of hospital stay after pancreaticoduodenectomy (PD) have significantly decreased over recent decades. Despite this progress, early readmission rates PD been reported as high 50%. Few reports delineated factors associated with PD. Methods: The medical records 6 high-volume institutions were reviewed for patients who underwent between 2005 2010. Data collection included patient characteristics, comorbidities, perioperative...
PURPOSE Limited data exist on the optimal duration of immunotherapy, including for non–small-cell lung cancer (NSCLC). We present an exploratory analysis CheckMate 153, a largely community-based phase IIIb/IV study, to evaluate impact 1-year fixed-duration versus continuous therapy efficacy and safety nivolumab. METHODS Patients with previously treated advanced NSCLC received nivolumab monotherapy (3 mg/kg every 2 weeks). Those still receiving treatment at 1 year, patients perceived be...
Background: We hypothesized that a novel surgical method, in which three-dimensional (3-D) preoperative planning software is generated to create patient-specific model used with reusable and adjustable tool, could substantially improve the positioning accuracy of glenoid guide pin total shoulder arthroplasty. tested this method using bone models from patients pathology compared results those achieved methods representing current standard care. Methods: Three surgeons variety experience...
A rhesus monkey was trained to perform individuated and combined finger flexions of the thumb, index, middle finger. Nine implantable myoelectric sensors (IMES) were then surgically implanted into muscles monkey's forearm, without any adverse effects over two years postimplantation. Using an inductive link, EMG wirelessly recorded from IMES as performed a flexion task. The different implants showed very little cross correlation. An offline parallel linear discriminant analysis (LDA) based...
A digital focal plane array (DFPA) architecture has been developed that incorporates per-pixel full-dynamic-range analog-to-digital conversion and orthogonal-transfer-based realtime signal processing capability. Several long-wave infrared-optimized pixel readout integrated circuit (ROIC) designs have implemented, each accommodating a 256 times 30-mum-pitch detector array. Demonstrated in this paper is the application of DFPA ROIC to problems background pedestal mitigation, wide-field...
Group B Streptococcus (GBS) can be found to colonize about 25% of all healthy, adult women and is the leading infectious cause early neonatal morbidity mortality in United States. This study evaluated clinical performance PhenoMatrix (PM) chromogenic detection module (CDM) digital imaging software GBS from LIM broth plated on ChromID Strepto medium (ChromID) using WASP automated processor. The PM CDM was compared manual culture review images molecular GBS.
Abstract G‐protein‐coupled receptor kinases (GRKs) are involved in cardiac hypertrophy and failure. But their temporal expression cellular localization during the development of its transition to failure remains be investigated. In this study, we determined subcellular distribution GRK2, GRK3, GRK5, GRK6 myocytes 2‐ 24‐month‐old spontaneously hypertensive heart (SHHF) rats. GRK2 increased intercalated disks 6‐, 12‐, SHHF rats, although total remained relatively constant from 2 24 months both...
We trained a rhesus monkey to perform individuated and combined finger flexions extensions of the thumb, index, middle finger. A Utah Electrode Array (UEA) was implanted into hand region motor cortex contralateral monkey's hand. also microwire electrocorticography grid (µECoG) epidurally so that it covered UEA. The µECoG spanned arm regions both primary somatosensory cortices. Previously this had Implantable MyoElectric Sensors (IMES) surgically muscles forearm. Action potentials (APs),...
Since 2006, MIT Lincoln Laboratory has been developing Digital-pixel Focal Plane Array (DFPA) readout integrated circuits (ROICs). To date, four 256 × 30 μm pitch DFPA designs with in-pixel analog to digital conversion have fabricated using IBM 90 nm CMOS processes. The ROICs are compatible a wide range of detector materials and cutoff wavelengths; HgCdTe, QWIP, InGaAs photo-detectors wavelengths ranging from 1.6 14.5 hybridized the same digital-pixel readout. architecture offers high...
Objective The performance of machine learning algorithms used for neural decoding dexterous tasks may be impeded due to problems arising when dealing with high-dimensional data. objective feature selection is choose a near-optimal subset features from the original space improve algorithm. aim our study was compare effects four techniques, Wilcoxon signed-rank test, Relative Importance, Principal Component Analysis, and Mutual Information Maximization on SVM classification task. Approach A...
This paper describes a predictive model using MATLAB machine learning tools for nonlinear regression, support vector and neural network. Data center performance measures such as run time, waiting time energy consumption, are predicted based on past events, total workload input number of IT resources. Predictive analytics enables evidence-based decision making in the case uncertainty risk, helps to evaluate areas improvement.
Dexterous finger movements can be decoded from neuronal action potentials acquired a nonhuman primate using chronically implanted Utah Electrode Array. We have developed an algorithm that can, after training, detect and classify individual combined without any priori knowledge of the data, task, or behavior. The is based on changes in firing rates neurons are tuned for one more movement types. Nine different types, which consisted flexions, extensions, flexions thumb, index finger, middle...
Studies of ipilimumab have shown improved overall survival in patients with metastatic cutaneous melanoma. As a result, use Stage IV melanoma is rapidly increasing. Patients often require urgent operations for complications from metastases, but little known about the safety surgical intervention receiving ipilimumab. We performed systematic review literature using PubMed. Our search terms were and excluded foreign language articles, those not addressing identified 194 publications matching...
We trained a rhesus monkey to perform randomly cued, individuated finger flexions of the thumb, index, and middle finger. Nine Implantable MyoElectric Sensors (IMES) were then surgically implanted into muscles monkey's forearm, without any observable adverse chronic effects. Using an inductive link, we wirelessly recorded EMG from IMES as performed flexion task. A principal components analysis (PCA) based algorithm was used decode which switch pressed on EMG. This correctly decoded moved 89%...