A5091923872- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- CRISPR and Genetic Engineering
- Algal biology and biofuel production
- Asymmetric Hydrogenation and Catalysis
- Enzyme Production and Characterization
- Chemical Reactions and Isotopes
- Viral Infectious Diseases and Gene Expression in Insects
Forschungszentrum Jülich
2024
RWTH Aachen University
2023
The inevitable transition from petrochemical production processes to renewable alternatives has sparked the emergence of biofoundries in recent years. Manual engineering microbes will not be sufficient meet ever-increasing demand for novel producer strains. Here we describe AutoBioTech platform, a fully automated laboratory system with 14 devices perform operations strain construction without human interaction. Using modular workflows, this platform enables transformations Escherichia coli...
In research and production, reproducibility is a key factor, to meet high quality safety standards maintain productivity. For microbial fermentations, complex substrates media components are often used. The can vary in composition, depending on the lot manufacturing process. These variations have an immense impact results of biological cultivations. aim this work was investigate characterize influence component yeast extract cultivations Azotobacter vinelandii under microaerobic conditions....
The engineering of stereoselective C-methyltransferase PsmD through saturation mutagenesis led to improved activity for larger substrates. An automated process was designed and successfully applied the mutant library production screening.