A5057447467- Microbial Metabolic Engineering and Bioproduction
- Viral Infectious Diseases and Gene Expression in Insects
- Enzyme Catalysis and Immobilization
- Plant biochemistry and biosynthesis
- CRISPR and Genetic Engineering
- Biochemical and biochemical processes
- biodegradable polymer synthesis and properties
Forschungszentrum Jülich
2023-2024
RWTH Aachen University
2024
The inevitable transition from petrochemical production processes to renewable alternatives has sparked the emergence of biofoundries in recent years. Manual engineering microbes will not be sufficient meet ever-increasing demand for novel producer strains. Here we describe AutoBioTech platform, a fully automated laboratory system with 14 devices perform operations strain construction without human interaction. Using modular workflows, this platform enables transformations Escherichia coli...
Phenylpropanoids such as p-coumaric acid represent important precursors for the synthesis of a broad range plant secondary metabolites including stilbenoids, flavonoids, and lignans, which are pharmacological interest due to their health-promoting properties. Although extraction from material or chemical is possible, microbial glucose has advantage being less expensive more resource efficient. In this study, Corynebacterium glutamicum was engineered production polyphenol precursor...