A5102717296- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Statistical Methods in Clinical Trials
- Heavy Metal Exposure and Toxicity
- Extracellular vesicles in disease
- Heavy metals in environment
- CAR-T cell therapy research
- Atomic and Subatomic Physics Research
- COVID-19 diagnosis using AI
- Air Quality and Health Impacts
- Medication Adherence and Compliance
- Integrated Circuits and Semiconductor Failure Analysis
- Diabetes Treatment and Management
Wuhan Polytechnic University
2024-2025
Zhengzhou Children's Hospital
2024
Zhengzhou University
2024
Nanchang University
2023
University of Pittsburgh
2023
Abstract Background Extensive research has explored the association between heavy metal exposure and various health outcomes, including malignant neoplasms, hypertension, diabetes, heart diseases. This study aimed to investigate relationship patterns of a mixture seven metals these outcomes. Methods Blood samples from 7,236 adults in NHANES 2011–2016 studies were analyzed for levels cadmium, manganese, lead, mercury, selenium, copper, zinc. Cluster analysis logistic regression identified...
Abstract Exosomal long noncoding RNAs (lncRNA) derived from cancer cells are implicated in various processes, including cell proliferation, metastasis, and immunomodulation. We investigated the role underlying mechanism of exosome-transmitted lncRNA NEAT1 immune escape multiple myeloma natural killer (NK) cells. Multiple samples patients with were obtained. The effects cell-derived exosomes (multiple exosomes) exosomal on functions NK evaluated using EdU staining, CCK-8, flow cytometry,...
Abstract Chimeric antigen receptor T (CAR-T) cells therapy has made remarkable progress in relapsed/refractory multiple myeloma (R/R MM) treatment. Unfortunately, patients still eventually experience disease progression or relapse even after receiving anti-BCMA CAR-T therapy. At present, there are limited data on available treatment options for who have progressed In this study, we evaluated the safety and efficacy of fully human (HRC0202) seven R/R MM were previously exposed to Three...
<div>Abstract<p>Exosomal long noncoding RNAs (lncRNA) derived from cancer cells are implicated in various processes, including cell proliferation, metastasis, and immunomodulation. We investigated the role underlying mechanism of exosome-transmitted lncRNA NEAT1 immune escape multiple myeloma natural killer (NK) cells. Multiple samples patients with were obtained. The effects cell-derived exosomes (multiple exosomes) exosomal on functions NK evaluated using EdU staining, CCK-8,...
<p>Supplementary Figure Legends 1-4</p>
<p>Supplementary Figure 4 shows that NK cells treated with MM exosomes released from U266 could modulate cell function through regulating PBX1.</p>
<p>Supplementary Figure 4 shows that NK cells treated with MM exosomes released from U266 could modulate cell function through regulating PBX1.</p>
<p>Supplementary Figure 2 shows that MM exosomes derived from U266 cells or NEAT1 knockdown had no effect on EZH2 expression.</p>
<p>Supplementary Figure 2 shows that MM exosomes derived from U266 cells or NEAT1 knockdown had no effect on EZH2 expression.</p>
<p>Supplementary Figure 1 shows that MM exosomes derived from U266 cells inhibit the proliferation and activity of NK but enhance cells’ apoptosis, while NEAT1 knockdown have lost this function.</p>
<p>Supplementary Figure 3 shows that MM exosomes derived from U266 cells NEAT1 knockdown ehance the proliferation and activity of NK but suppress cells’ apoptosis, while PBX1 reverses this function.</p>
<p>Supplementary Figure 1 shows that MM exosomes derived from U266 cells inhibit the proliferation and activity of NK but enhance cells’ apoptosis, while NEAT1 knockdown have lost this function.</p>
<p>Supplementary Figure 3 shows that MM exosomes derived from U266 cells NEAT1 knockdown ehance the proliferation and activity of NK but suppress cells’ apoptosis, while PBX1 reverses this function.</p>
<p>Supplementary Figure Legends 1-4</p>
<div>Abstract<p>Exosomal long noncoding RNAs (lncRNA) derived from cancer cells are implicated in various processes, including cell proliferation, metastasis, and immunomodulation. We investigated the role underlying mechanism of exosome-transmitted lncRNA NEAT1 immune escape multiple myeloma natural killer (NK) cells. Multiple samples patients with were obtained. The effects cell-derived exosomes (multiple exosomes) exosomal on functions NK evaluated using EdU staining, CCK-8,...