A5092403477- Congenital heart defects research
- Pregnancy and Medication Impact
- Mesenchymal stem cell research
- COVID-19 Impact on Reproduction
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Glioma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Cerebrospinal fluid and hydrocephalus
- Renal and related cancers
- Reproductive System and Pregnancy
- RNA Research and Splicing
University of Amsterdam
2023-2024
Amsterdam University Medical Centers
2023-2024
University Medical Center
2024
Uppsala University
2023
Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue investment barrier enclosure brain. The exact nature leptomeningeal cells has long been debated. In this study, we identify five molecularly distinct fibroblast-like transcriptomes in cerebral leptomeninges; link them to anatomically cell types pia, inner outer arachnoid barrier, dural border layer; contrast sixth transcriptome present choroid plexus median eminence. Newly identified transcriptional markers...
Early placenta development involves cytotrophoblast differentiation into extravillous trophoblast (EVT) and syncytiotrophoblast (STB). Defective function may result in severe pregnancy complications, including fetal growth restriction pre-eclampsia. The incidence of these complications is increased pregnancies fetuses affected by Rubinstein–Taybi syndrome, a developmental disorder predominantly caused heterozygous mutations CREB-binding protein ( CREBBP ) or E1A-binding p300 EP300 )....
IntroductionThe safety of COVID-19 mRNA vaccination during pregnancy is still a topic concern. The effects on placenta development have been poorly studied, even though correct essential for healthy outcomes. Here we investigated the effect maternal immune response to syncytiotrophoblast (STB), which forms functional cell layer where maternal-fetal exchange takes place.MethodsSerum samples were collected from pregnant women before and after second with Pfizer-BioNTech vaccine (n=12 paired...
Placentation disorders, including severe preeclampsia and fetal growth restriction, have their origins in early pregnancy, whereas symptoms typically present later on. To investigate the pathogenesis of these diseases, there is a need for reliable vitro model system placenta development with known pregnancy outcomes. Therefore, we optimized generation human induced trophoblast stem cells (iTSCs) from term umbilical cord, enabling non-invasive collection patient-derived material immediately...