A5102378103- Genetic and Kidney Cyst Diseases
- Biomedical Research and Pathophysiology
- Hedgehog Signaling Pathway Studies
- Amyotrophic Lateral Sclerosis Research
- Erythrocyte Function and Pathophysiology
- Genetic Syndromes and Imprinting
- Congenital heart defects research
- Renal Diseases and Glomerulopathies
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Nasal Surgery and Airway Studies
- Neurological diseases and metabolism
- Multisensory perception and integration
- Neuroscience and Neuropharmacology Research
ShanghaiTech University
2024
Shanghai Medical College of Fudan University
2022
University of Sheffield
2018-2019
National University of Singapore
2003
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal genetic disorder, however it still lacks a cure. The discovery of new therapies heavily depends on understanding key signalling pathways that lead to ADPKD. JA nus K inase and S ignal T ransducers A ctivators ranscription (JAK/STAT) pathway aberrantly activated contributes ADPKD pathogenesis via enhancing epithelial proliferation. Yet mechanisms underlying upregulation JAK/STAT activity in this context...
OBJECTIVE We sought to investigate the pattern, duration, and amplitude of nasal cycle its response decongestant. STUDY DESIGN AND SETTING Ten adult volunteers attended 2 sessions (with without spray 0.1% xylometazoline) for consecutive examinations by rhinomanometry acoustic rhinometry every 10 minutes over 6 hours. RESULTS: A spontaneous fluctuation in minimum cross‐sectional area, volume, resistances (inspiration expiration) could be observed measurement. significant negative correlation...
ABSTRACT Dysregulated JAK/STAT signalling is implicated in polycystic kidney disease, which a common genetic disease leading to renal failure. However, the mechanisms underlying JAK/STAT-mediated cystogenesis arepoorlyunderstood.TheroleofJAK2wasinvestigated immunohistochemically murine model of cystic (Pkd1 nl/nl ). In normal kidney, JAK2 restricted tubular epithelial and vascular cells with lesser staining bowman’s capsule undetectable interstitium. By contrast, diseased appears stronger...