A5049942090- Gut microbiota and health
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Parkinson's Disease Mechanisms and Treatments
- Molecular Communication and Nanonetworks
- Child Nutrition and Feeding Issues
- Oral and gingival health research
- Cancer Cells and Metastasis
- Pancreatitis Pathology and Treatment
- Mitochondrial Function and Pathology
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Genetic Neurodegenerative Diseases
- Microfluidic and Bio-sensing Technologies
University of Luxembourg
2020-2024
Abstract The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, crosstalk between host relation to cell metabolism remains largely unexplored. Here we show that formate, metabolite produced by CRC-associated bacterium Fusobacterium nucleatum , promotes CRC development. We describe molecular signatures linking phenotypes with abundance. Cocultures of F....
The human microbiome significantly influences drug metabolism through the gut-liver axis, leading to modified responses and potential toxicity. Due complex nature of gut environment, understanding microbiome-driven impacts on these processes is limited. To address this, a multiorgan-on-a-chip (MOoC) platform that combines microbial-crosstalk (HuMiX) gut-on-chip (GoC) Dynamic42 liver-on-chip (LoC), mimicking bidirectional interconnection between liver known as introduced. This supports...
Abstract In healthy individuals, the intestinal epithelium forms a tight barrier to prevent gut bacteria from reaching blood circulation. To study effect of probiotics, dietary compounds and drugs on formation disruption, human epithelial bacterial cells can be cocultured in an vitro model called microbial crosstalk (HuMiX) gut-on-a-chip system. Here, we present design, fabrication integration thin-film electrodes into HuMiX platform measure transepithelial electrical resistance (TEER) as...
Parkinson's disease (PD) is a neurological disorder characterized by motor dysfunction, dopaminergic neuron loss, and alpha-synuclein (αSyn) inclusions. Many PD risk factors are known, but those affecting progression not. Lifestyle microbial dysbiosis candidates in this context. Diet-driven gut reduced barrier function may increase exposure of enteric neurons to toxins. Here, we study whether fiber deprivation bacterial curli, protein cross-seeding with αSyn, individually or together,...
Several mutations in Leucine-rich repeat kinase-2 (LRRK2) have been associated with Parkinson's disease (PD). The most common substitution, G2019S, interferes LRRK2 kinase activity, which is regulated by autophosphorylation. Yet, the penetrance of this gain-of-function mutation incomplete, and thus far, few factors correlated status carriers. This includes (i) autophosphorylation urinary exosomes, (ii) serum levels antioxidant urate, (iii) abundance mtDNA transcription-associated 7S DNA. In...
The human body is colonized by at least the same number of microbial cells as it composed cells, and most these microorganisms are located in gut. Though interplay between gut microbiome host has been extensively studied, how interacts with enteric nervous system remains largely unknown. To date, a physiologically representative vitro model to study microbiome-nervous interactions does not exist. fill this gap, we further developed human-microbial crosstalk (HuMiX) gut-on-chip introducing...
Abstract Accumulating evidence suggests that dysbiosis, a state of pathologic imbalance in the human gut microbiome, is present patients suffering from colorectal cancer (CRC). Several microbiome studies identified specific bacteria are associated with CRC, among which Fusobacteria were shown to directly interact or immune cells their host. However, only limited number CRC-associated microbes have been studied for host-microbial interactions; hence, role etiology disease remains unknown....
The human body is colonized by at least the same number of microbial cells as it composed cells, and most these microorganisms are located in gut. Though interplay between gut microbiome host has been extensively studied, how interacts with enteric nervous system remains largely unknown. To date, a physiologically representative vitro model to study microbiome-nervous interactions does not exist. fill this gap, we further developed human-microbial crosstalk (HuMiX) gut-on-chip introducing...