A5080260741- RNA modifications and cancer
- RNA Research and Splicing
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Bone health and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Animal Genetics and Reproduction
- Chromatin Remodeling and Cancer
- Cancer-related gene regulation
- Medical Imaging and Pathology Studies
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Protein Structure and Dynamics
- Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
Huazhong University of Science and Technology
2021-2024
Tongji Hospital
2021-2024
Abstract N6‐methyladenosine (m 6 A) modification orchestrates cancer formation and progression by affecting the tumor microenvironment (TME). For hepatocellular carcinoma (HCC), immune evasion angiogenesis are characteristic features of its TME. The role YTH RNA binding protein 2 (YTHDF2), as an m A reader, in regulating HCC TME not fully understood. Herein, it is discovered that trimethylated histone H3 lysine 4 27 acetylation promoter region YTHDF2 enhanced expression HCC, upregulated...
Abstract Bone is the second leading metastatic site for hepatocellular carcinoma (HCC). Patients with HCC and bone metastasis suffer poor quality of life reduced survival time. Extracellular vesicles (EVs) are widely involved in formation metastasis. However, communication between primary lesions mediated by EVs remains unclear possible effect on progression largely unknown. Here, bone‐metastasized HCC‐derived (BM‐EVs) found to localize orthotropic cells promote progression. Mechanistically,...
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with high mortality. Advanced stage upon diagnosis and cancer metastasis are main reasons for dismal prognosis HCC in large part. The role proliferation associated protein 2G4 (PA2G4) tumorigenesis progression has been widely investigated various cancers. However, whether how PA2G4 participates still underexplored. We found that mRNA levels were higher samples than normal liver tissues, expression was correlated a...
Background and Aims: HCC is a highly heterogeneous disease that caused largely by genomic copy number variations. Herein, the mechanistic therapeutically targeted role of vacuolar protein sorting 72 homologue (VPS72), novel variation cis-driven gained gene identified genome-wide transcriptome analyses in HCC, not well understood. Approach Results: First, overexpression VPS72 enhanced initiation progression vitro vivo . Mechanistically, interacted with oncoproteins MYC actin-like 6A (ACTL6A)...
Abstract Cholangiocarcinoma (CCA) is characterized by rapid onset and high chance of metastasis. Therefore, identification novel therapeutic targets imperative. E26 transformation‐specific homologous factor (EHF), a member the transcription family, plays pivotal role in epithelial cell differentiation cancer progression. However, its precise CCA remains unclear. In this study, through vitro vivo experiments, we demonstrated that EHF profound promoting transcriptional activation...
Abstract cAMP responsive element binding protein 3 (CREB3), belonging to bZIP family, was reported play multiple roles in various cancers, but its role hepatocellular carcinoma (HCC) is still unclear. like (CREB3L3), another member of thought be transcription factor (TF) regulate hepatic metabolism. Nevertheless, except for being TFs, other function family were poorly understood. In this study, we found CREB3 inhibited growth and metastasis HCC vitro vivo. RNA sequencing indicated regulated...
Hepatocellular carcinoma (HCC) has been recognized as the third leading cause of cancer-related deaths worldwide. There is increasing evidence that abnormal expression autophagy-related genes plays an important role in occurrence and development HCC. Therefore, study can further elucidate genetic drivers cancer provide valuable therapeutic targets for clinical treatment. In this study, we used 232 extracted from Human Autophagy Database (HADb) Molecular Signatures (MSigDB) to construct 1884...