A5092957079- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Pharmaceutical studies and practices
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Analytical Chemistry and Chromatography
- Blood disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Liver Diseases and Immunity
- Biochemical Analysis and Sensing Techniques
- Celiac Disease Research and Management
Emma Kinderziekenhuis
2023-2025
Amsterdam University Medical Centers
2023-2025
University of Amsterdam
2024-2025
Abstract Background Methotrexate (MTX) is frequently prescribed in paediatric inflammatory bowel disease (IBD), with laboratory monitoring routinely performed to detect adverse events (AEs) such as hepatotoxicity and myelotoxicity. However, data on the incidence of these AEs IBD remain limited. This study aims assess MTX-induced IBD, identify factors associated AEs. Methods We conducted a retrospective monocentre cohort study, including all patients initiating MTX at Amsterdam UMC between...
Therapeutic drug monitoring (TDM) of methotrexate (MTX) is challenging due to its pharmacokinetics and short plasma half-life. Intracellular MTX-polyglutamates (PG1-5), which accumulate over time, have not been assessed in pediatric inflammatory bowel disease (IBD). This study aimed evaluate erythrocyte MTX-PG as a potential TDM tool IBD. In this cross-sectional study, concentrations were measured erythrocytes children with IBD on stable low-dose MTX for at least 12 weeks using...
The gut microbiota and its related metabolites differ between inflammatory bowel disease (IBD) patients healthy controls. In this study, we compared faecal volatile organic compound (VOC) patterns of paediatric IBD controls with gastrointestinal symptoms (CGIs). Additionally, aimed to assess if baseline VOC profiles could predict treatment response in patients. We collected samples from a cohort de novo therapy-naïve CGIs. VOCs were analysed using gas chromatography–ion mobility spectrometry...
Abstract Background Methotrexate (MTX) is increasingly prescribed in paediatric inflammatory bowel disease (IBD), but therapeutic drug monitoring (TDM) currently not feasible due to its characteristic pharmacokinetics and short half-life plasma, which amounts approximately 2.5-6.5 hours. Because of this, plasma MTX no longer detectable shortly after administration. However, MTX-polyglutamates (PG1-5) are formed intracellularly accumulate over time. Recently, we developed a technique for...
Abstract Background Paediatric inflammatory bowel disease (IBD) patients have an increased risk of colorectal cancer (CRC). Current guidelines advise to conduct CRC surveillance colonoscopy eight years following IBD diagnosis, or more often in case other factors for are present, such as previous findings dysplasia, a concomitant primary sclerosing cholangitis (PSC) diagnosis. However, these based on adult data and with no regard the patient’s age, while frequent endoscopies impose...