A5070498535- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Bladder and Urothelial Cancer Treatments
- DNA Repair Mechanisms
- Esophageal Cancer Research and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Systemic Sclerosis and Related Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pulmonary Hypertension Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Enzyme Structure and Function
- Spondyloarthritis Studies and Treatments
- Lung Cancer Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Trypanosoma species research and implications
- Genomics, phytochemicals, and oxidative stress
- Lysosomal Storage Disorders Research
BresMed
2016-2021
University of Sheffield
2015-2016
Ollscoil na Gaillimhe – University of Galway
2016
Beth Israel Deaconess Medical Center
2014
Harvard University
2014
Hebrew SeniorLife
2014
Royal Adelaide Hospital
2005-2013
Monash Medical Centre
2012
Royal Perth Hospital
2012
Royal Prince Alfred Hospital
2012
Cyclin-dependent kinases (CDKs) coordinate cell cycle checkpoints with DNA repair mechanisms that together maintain genome stability. However, the myriad can give rise to instability are still be fully elucidated. Here, we identify CDK18 (PCTAIRE 3) as a novel regulator of stability, and show depletion causes an increase in endogenous damage chromosomal abnormalities. CDK18-depleted cells accumulate early S-phase, exhibiting retarded replication fork kinetics reduced ATR kinase signaling...
<h3>Introduction</h3> Postoperative delirium is one of the most common complications major surgery, affecting 10–70% surgical patients 60 years and older. Delirium an acute change in cognition that manifests as poor attention illogical thinking associated with longer intensive care unit (ICU) hospital stay, long-lasting cognitive deterioration increased mortality. Ketamine has been used anaesthetic drug for over 50 established safety record. Recent research suggests that, addition to...
RECQL5 is a member of the RecQ family DNA helicases and has key roles in homologous recombination, base excision repair, replication transcription. The clinicopathological significance expression breast cancer unknown. In this study, we have evaluated mRNA 1977 cancers, protein level 1902 cancers [Nottingham Tenovus series ( n = 1650) ER− cohort 252)]. Expression levels were correlated to aggressive phenotypes survival outcomes. High was significantly associated with high histological grade...
IntroductionPembrolizumab has been approved in the United States (US) for first-line treatment of patients with advanced or metastatic urothelial carcinoma, who are ineligible cisplatin-containing chemotherapy and tumors expressing programmed death-ligand 1 (PD-L1) (Combined Positive Score ≥ 10), any platinum-containing regardless PD-L1 status. Long-term KEYNOTE-052 data continue to demonstrate pembrolizumab's meaningful, durable, well-tolerated antitumor activity. This study evaluates...
There is an unmet need for effective therapies patients with advanced or metastatic urothelial cancer who cannot tolerate cisplatin-based chemotherapy. Cisplatin-ineligible experience a high frequency of adverse events from the most commonly used standard care treatment, carboplatin plus gemcitabine, alternative treatment gemcitabine monotherapy. Pembrolizumab potent, highly selective humanised monoclonal antibody that releases checkpoint inhibition immune response system, and provides new...
// Karl Patterson 1 , Lovleen Arya 1, * Sarah Bottomley Susan Morgan 2 Angela Cox James Catto Helen E. Bryant Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), Department Oncology and Metabolism, University Sheffield, S10 2RX, United Kingdom Urology, Current address: DuPont Knowledge Center, E.I.DuPont India Pvt Ltd., ICICI Park, Genome Valley, Hyderabad-500078, Andhra Pradesh, Correspondence to: Bryant, email: h.bryant@sheffield.ac.uk Keywords: RECQL5,...
Nivolumab with ipilimumab (the Regimen) is the first immuno-oncology combination treatment to demonstrate long-term clinical benefit for advanced melanoma patients. We evaluated cost effectiveness of Regimen in this population, and without availability overall survival (OS) data.A partitioned model a Markov state-transition were developed estimate lifetime costs benefits versus ipilimumab. These models built OS data, as only progression-free data available from head-to-head, phase III trial...
For some immune-mediated disorders, despite the range of therapies available there is limited evidence on which treatment sequences are best for patients and healthcare systems. We investigated how their selection can impact outcomes in an Italian setting. A 3-year state-transition treatment-sequencing model calculated potential effectiveness improvements budget reallocation considerations associated with implementing optimal ankylosing spondylitis (AS), Crohn's disease (CD),...
Combination treatment with pegylated interferon (Peg-IFN) and ribavirin remains the gold standard in of chronic hepatitis C. This therapy is limited by many side-effects including anaemia, neutropenia reduced quality life. The use adjuvant agents to reduce frequency dose reductions because haematological has been proven be effective but there are few reports what effect these therapies having on sustained virological response (SVR). aim study was assess clinical impact during combination...
Introduction. Pulmonary arterial hypertension (PAH) is a major cause of mortality in SSc. NT-proBNP may be useful biomarker prevalent PAH but its role screening for incident has not been evaluated. Methods. Patients recruited into the Australian Scleroderma Cohort Study undergo annual echocardiography, pulmonary function tests (PFTs), 6-min walk test (6MWT) and have serum measured (ElecsysproBNP II). The diagnosis based on Dana point criteria at right heart catheterization (RHC). with LV...
93 Background: Pembrolizumab is indicated as first-line therapy for cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma (mUC) whose tumors express PD-L1 a combined positive score (CPS) ≥ 10. This study aims to evaluate the cost‐effectiveness of pembrolizumab versus carboplatin plus gemcitabine in this setting from US payer perspective. Methods: A partitioned-survival model was developed measure costs and effectiveness over 20-year time horizon an annual...
<h3>Background</h3> Pulmonary Arterial Hypertension (PAH) is a major cause of mortality in SSc. N-terminal pro-brain natriuretic peptide (NT-proBNP) has emerged as candidate biomarker that may enable the early detection systemic sclerosis-related pulmonary arterial hypertension (SSc-PAH). <h3>Objectives</h3> To incorporate into screening algorithm for (SSc-PAH) could potentially replace transthoracic echocardiography (TTE) less costly and more convenient “first tier” test. <h3>Methods</h3>...