A5113846131- Geography and Environmental Studies in Latin America
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Adsorption, diffusion, and thermodynamic properties of materials
- RNA modifications and cancer
- Synthesis and characterization of novel inorganic/organometallic compounds
- Chemical Reactions and Isotopes
- Engine and Fuel Emissions
- Organometallic Complex Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- Analytical Chemistry and Chromatography
- Botany and Plant Ecology Studies
- Toxic Organic Pollutants Impact
Institute of Protein Research
2024
Lomonosov Moscow State University
1996-2024
Moscow State University
2024
Queen's University
2001
SUMMARY We describe an effort (“Codebook”) to determine the sequence specificity of 332 putative and largely uncharacterized human transcription factors (TFs), as well 61 control TFs. Nearly 5,000 independent experiments across multiple in vitro vivo assays produced motifs for just over half TFs analyzed (177, or 53%), which most are unique a single TF. The data highlight extensive contribution transposable elements TF evolution, both cis trans , identify tens thousands conserved, base-level...
Abstract A DNA sequence pattern, or “motif”, is an essential representation of DNA-binding specificity a transcription factor (TF). Any particular motif model has potential flaws due to shortcomings the underlying experimental data and computational discovery algorithm. As part Codebook/GRECO-BIT initiative, here we evaluated at large scale cross-platform recognition performance positional weight matrices (PWMs), which remain popular models in many practical applications. We applied ten...
Abstract The paper presents results on behavioral studies of PAHs in different types soils connection with the soil-forming processes and character anthropogenic influence soil cover. data obtained showed a considerable accumulation low molecular weight PAHs, partly natural origin, subsurface deep horizons depending intensity contamination, activity biota, leaching solution, etc. On contrary, vertical distribution high compounds (e.g. benzo(a)pyrene, etc.), mostly are characterized by strong...
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