A5093525394- Trypanosoma species research and implications
- Malaria Research and Control
- Endoplasmic Reticulum Stress and Disease
- Drug Transport and Resistance Mechanisms
La Trobe University
2023-2024
Apical membrane antigen-1 (AMA1) is a conserved malarial vaccine candidate essential for the formation of tight junctions with rhoptry neck protein (RON) complex, enabling Plasmodium parasites to invade human erythrocytes, hepatocytes, and mosquito salivary glands. Despite its critical role, extensive surface polymorphisms in AMA1 have led strain-specific protection, limiting success AMA1-based interventions beyond initial clinical trials. Here, we identify an i-body, humanised single-domain...
<title>Abstract</title> Broadly cross-reactive anti-malarial vaccines and therapeutic interventions are needed to achieve better outcomes in controlling and, eventually, eradicating malaria. Apical membrane antigen-1 (AMA1) is a structurally functionally conserved malarial vaccine candidate involved the tight junction formation with rhoptry neck protein (RON) complex at host cell-parasite interface. This interaction crucial for all <italic>Plasmodium </italic>parasites invade human...