A5068997268- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hydrogen's biological and therapeutic effects
- Telomeres, Telomerase, and Senescence
Ludwig-Maximilians-Universität München
2025
University of Groningen
2022-2024
University Medical Center Groningen
2022-2024
<title>Abstract</title> Co-translational N-terminal modifications such as methionine excision, acetylation, and myristoylation contribute to protein stability, localization, folding (1). Disrupting these exposes short degron motifs that trigger degradation via the ubiquitin-proteasome system, safeguarding proteome (2). While acetylation typically protects proteins, it may also promote through Ac/N-degron pathway (3). Src family kinases (SFKs), key regulators of signaling tumorigenesis,...
Higher levels of cellular senescence have been demonstrated in COPD patients, including severe early onset (SEO)-COPD. Recently we a link between and extracellular matrix (ECM) changes lung fibroblasts. Whether this vitro observation also translates vivo has not yet. Therefore, aimed to determine whether can contribute COPD-associated ECM-related tissue. Transcriptomics proteomics analyses were performed on tissue from 60 patients (including 18 SEO-COPD patients) 32 controls. Transcript...
<b>Background:</b> Severe early onset (SEO-)COPD manifests at age (≤ 55 years) compared to common COPD. What drives this is currently unclear. We hypothesize that its pathogenesis differs from <b>Aim:</b> To determine whether SEO-COPD has a distinct gene expression profile helps understand and difference with <b>Methods:</b> RNA sequencing was done lung resection tissue of 18 SEO-COPD, 20 moderate-severe (MS-)COPD 30 non-COPD control subjects. A signature specific for identified by comparing...