A5018019793- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- Oral microbiology and periodontitis research
- Alkaline Phosphatase Research Studies
- Immune Response and Inflammation
- Photosynthetic Processes and Mechanisms
- Infant Nutrition and Health
- dental development and anomalies
- Plant Gene Expression Analysis
- Shoulder Injury and Treatment
- Pancreatitis Pathology and Treatment
- Bone Tissue Engineering Materials
- NF-κB Signaling Pathways
- Flavonoids in Medical Research
- Oral and Maxillofacial Pathology
- Plant Stress Responses and Tolerance
- Galectins and Cancer Biology
- Stress Responses and Cortisol
- Inflammatory mediators and NSAID effects
- Curcumin's Biomedical Applications
- Connective tissue disorders research
- Amoebic Infections and Treatments
- Neurogenetic and Muscular Disorders Research
- Cancer, Stress, Anesthesia, and Immune Response
- Tryptophan and brain disorders
Northeast Normal University
2024
Inner Mongolia University for Nationalities
2024
Hiroshima University
2012-2018
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2015-2018
National Institutes of Health
2015-2018
Background Epidemiological studies have revealed a link between dental infection and preterm birth or low weight (PTB/LBW), however, the underlying mechanisms remain unclear. Progress in understanding associated has been limited part by lack of an animal model for chronic infection-induced PTB/LBW, mimicking pregnancy under conditions periodontitis. We aimed to establish mouse periodontitis order investigate PTB/LBW. Methods To inflammation beginning with infection, we surgically opened...
Lactoferrin (LF) is an important modulator of the immune response and inflammation. It has also been implicated in regulation bone tissue. In our previous study we demonstrated that bovine LF (bLF) reduces LPS-induced resorption through a reduction TNF-α production vivo. However, it was not known how bLF inhibits LPS-mediated RANKL (receptor activator nuclear factor κB ligand) osteoblasts. this show impairs production. inhibited osteoclastogenesis via osteoblasts co-culture system....
Background A number of studies have revealed a link between chronic periodontitis and cardiovascular disease in obese patients. However, there is little information about the influence periodontitis-associated bacteria, Porphyromonas gingivalis (Pg), on pathogenesis atherosclerosis obesity. Methods In vivo experiment: C57BL/6J mice were fed with high-fat diet (HFD) or normal chow (CD), as control. Pg was infected from pulp chamber. At 6 weeks post-infection, histological immunohistochemical...
Dental infection is risk for preterm birth (PTB) through unclear mechanisms. We established a dental infection-induced PTB mouse model, in which Porphyromonas gingivalis (P.g.) induced by 2 days. analysed pathogenic factors contributing to and their effects on trophoblasts vitro. TNF-α, IL-8, COX-2 were upregulated P.g.-infected placenta. Galectin-3 (Gal-3), an immune regulator, was significantly placenta, amniotic fluid, serum. In vitro, P.g.-lipopolysaccharide (P.g.-LPS) increased TNF-α...
Previous studies revealed that cementum formation is tightly regulated by inorganic pyrophosphate (PP i ), a mineralization inhibitor. Local PP concentrations are determined regulators, including ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), which increases adenosine triphosphate hydrolysis. Orthodontic forces stimulate alveolar bone remodelling, leading to orthodontic tooth movement (OTM). To better understand how disturbed mineral metabolism and the resulting altered...
Bone sialoprotein (BSP) is an acidic phosphoprotein with collagen-binding, cell attachment, and hydroxyapatite-nucleating properties. BSP expression in mineralized tissues upregulated at onset of mineralization. Bsp-null ( Bsp -/- ) mice exhibit reductions bone mineral density, turnover, osteoclast activation, impaired healing. Furthermore, have marked periodontal tissue breakdown, a lack acellular cementum leading to ligament detachment, extensive alveolar tooth root resorption, incisor...
The tooth root and periodontal apparatus, including the acellular cellular cementum, ligament (PDL), alveolar bone, are critical for function. Cementum bone mineralization is regulated by factors enzymes extracellular matrix proteins that promote or inhibit hydroxyapatite crystal growth. Orphan Phosphatase 1 ( Phospho1, PHOSPHO1) a phosphatase expressed chondrocytes, osteoblasts, odontoblasts functions in skeletal dentin initiating deposition of inside membrane-limited vesicles. role...
Abstract B-cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family genes play prominent roles in regulating plant growth, development, and stress response. Although the molecular mechanism underlying BAG’s response to abiotic has been studied Arabidopsis , function of OsBAG saline-alkaline tolerance rice remains unclear. In this study, OsBAG6, a chaperone regulator localized mitochondria, was identified as novel negative rice. The expression level OsBAG6 induced by high concentration...