A5028894913- Antimicrobial Peptides and Activities
- Protein Structure and Dynamics
- Receptor Mechanisms and Signaling
- Biochemical and Structural Characterization
- Nicotinic Acetylcholine Receptors Study
- Protein purification and stability
- Protein Hydrolysis and Bioactive Peptides
- Probiotics and Fermented Foods
Concordia University
2022-2024
Concordia University
2024
Short, cysteine-rich peptides can exist in stable or metastable structural ensembles due to the number of possible patterns formation their disulfide bonds. One interesting subset this peptide group is conotoxins, which are produced by aquatic snails family Conidae. The μ antagonists and blockers voltage-gated sodium channel, a folding spectrum: on one end spectrum more hirudin-like folders, form bonds then reshuffle them, leading an ensemble kinetically trapped isomers, other BPTI-like...
Antimicrobial peptides (AMPs) are of growing interest as potential candidates for antibiotics to which antimicrobial resistance increases slowly. In this article, we perform the first in silico study synthetic β sheet-forming AMP GL13K. Through atomistic simulations single and multipeptide systems under different charge conditions, able shine a light on short timescales early aggregation. We find that isolated peptide conformations primarily dictated by sequence rather than charge, whereas...
Antimicrobial peptides (AMPs) are of growing interest as potential candidates that may offer more resilience against antimicrobial resistance than traditional antibiotic agents. In this article, we perform the first in silico study synthetic ß sheet-forming AMP GL13K. Through atomistic simulations single and multi-peptide systems under different conditions, able to shine a light on short timescales early aggregation. We find isolated peptide conformations primarily dictated by sequence...
Abstract Short, cysteine-rich peptides can exist in stable or metastable structural ensembles due to the number of possible patterns formation their disulfide bonds. One interesting subset this peptide group is coonotoxins, which are produced by aquatic snails family Conidae . The µ conotoxins, antagonists and blockers voltage-gated sodium channel, a folding spectrum: on one end spectrum more hirudin-like folders, form bonds then reshuffle them, leading an ensemble kinetically trapped...