A5065590627- Bacteriophages and microbial interactions
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- Bacterial Genetics and Biotechnology
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Biochemical and Structural Characterization
- Nosocomial Infections in ICU
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Use and Resistance
- Respiratory Support and Mechanisms
- Diabetes Treatment and Management
- PARP inhibition in cancer therapy
- Complementary and Alternative Medicine Studies
- Bacterial Identification and Susceptibility Testing
- Infection Control in Healthcare
- Enterobacteriaceae and Cronobacter Research
- Cell death mechanisms and regulation
- SARS-CoV-2 detection and testing
- DNA Repair Mechanisms
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
University of Alabama at Birmingham
2017-2025
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
Intensive Care National Audit & Research Centre
2021
Public Health Scotland
2021
University Hospitals Birmingham NHS Foundation Trust
2021
Public Health England
2021
Oxford University Clinical Research Unit
2021
Eijkman Institute for Molecular Biology
2021
Staphylococcus aureus pathogenicity islands (SaPIs), such as SaPI1, exploit specific helper bacteriophages, like 80α, for their high frequency mobilization, a process termed ‘molecular piracy’. SaPI1 redirects the helper’s assembly pathway to form small capsids that can only accommodate smaller genome, but not complete phage genome. encodes two proteins, CpmA and CpmB, are responsible this size redirection. We have determined structures of 80α procapsids near-atomic resolution by...
Penicillin-sensitive and penicillin-resistant colonies of Staphylococcus aureus, belonging to the same phage pattern, were found in six out 200 apparently resistant cultures isolated from infective processes. The vitro instability peni-cillinase-producing strains Staph. aureus was confirmed. It that growth with Streptococcus haemolyticus or presence other antibiotics did not greatly influence natural development sensitive variants. This process, however, tended be accelerated by at 44°,...
ABSTRACT Tailed bacteriophages with double-stranded DNA genomes (class Caudoviricetes ) play an important role in the evolution of bacterial pathogenicity, both as carriers genes encoding virulence factors and main means horizontal transfer mobile genetic elements (MGEs) many bacteria, such Staphylococcus aureus . The S. pathogenicity islands (SaPIs), including SaPI1, are a type MGEs that carry variable complement factors. SaPI1 is mobilized at high frequency by “helper” bacteriophages, 80α,...
Journal Article Structure of the Streptococcus pneumoniae 70S Ribosome at 2.9 Å Resolution using Cryo-EM Get access Mohamed Nasef, Nasef Department Microbiology, The University Alabama in Birmingham, AL, United States Search for other works by this author on: Oxford Academic Google Scholar Laura Parker, Parker James Kizziah, Kizziah Terje Dokland Corresponding author: dokland@uab.edu Microscopy and Microanalysis, Volume 29, Issue Supplement_1, 1 August 2023, Pages 938–940,...
Staphylococcus aureus is a gram-positive opportunistic human pathogen and found to be the second leading for deaths associated with antimicrobial resistance (1).S. pathogenicity islands (SaPIs) are class of mobile genetic elements which code various virulence factors, including superantigen toxins toxic shock syndrome toxin-1 (2).SaPI1 DNA stably integrated into host genome, but can mobilized help specific 'helper' bacteriophage, such as 80α.When SaPI1 by 80α, it packaged transducing...
ABSTRACT Staphylococcus aureus is an important human pathogen, and the prevalence of antibiotic resistance a major public health concern. The evolution pathogenicity in S. often involves acquisition mobile genetic elements (MGEs). Bacteriophages play especially role, since transduction represents main mechanism for horizontal gene transfer. islands (SaPIs), including SaPI1, are MGEs that carry genes encoding virulence factors, mobilized at high frequency through interactions with specific...
Journal Article Staphylococcus aureus Pathogenicity Islands: Hijackers on the Bacteriophage Assembly Pathway. Get access Terje Dokland, Dokland Department of Microbiology, University Alabama at Birmingham, AL, U.S.A Search for other works by this author on: Oxford Academic Google Scholar James L Kizziah, Kizziah Altaira D Dearborn, Dearborn National Institute Arthritis and Musculoskeletal Skin Diseases, Bethesda, MD, Keith A Manning, Manning Erin Wall, Wall Microbiology Immunology, Virginia...
An abrupt change in baseline CDI from 2016 to 2017 prompted a response team task force including senior administration, the CMO, infection prevention, environmental services, laboratory, pharmacy, emergency department (ED), and nursing address problem. Hospital-acquired (HA) community-acquired (CA) cases were tracked using an epidemic curve institutional case mapping. A multipronged intervention was implemented that included molecular typing of isolates, quarterly terminal cleaning ED,...