A5005041112- Ion Channels and Receptors
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Occupational exposure and asthma
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antifungal resistance and susceptibility
- Pain Mechanisms and Treatments
- Genomics, phytochemicals, and oxidative stress
- Vascular Malformations and Hemangiomas
- Fungal Infections and Studies
- Neuroscience and Neural Engineering
- Multiple Myeloma Research and Treatments
- Probiotics and Fermented Foods
- Oral microbiology and periodontitis research
- Neurofibromatosis and Schwannoma Cases
- Ion channel regulation and function
- Pneumocystis jirovecii pneumonia detection and treatment
Ludwig-Maximilians-Universität München
2019-2024
German Center for Lung Research
2019-2024
Heidelberg University
2023
University Hospital Heidelberg
2023
University of Hong Kong
2016
Tamil Nadu Government Dental College and Hospital
2012
Ischemia/reperfusion-induced edema (IRE), one of the most significant causes mortality after lung transplantation, can be mimicked ex vivo in isolated perfused mouse lungs (IPL). Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel studied endothelium; however, its role epithelium remains elusive. Here, we show enhanced IRE TRPV4-deficient (TRPV4-/-) IPL compared with that WT controls, indicating protective TRPV4 maintenance alveolar epithelial barrier. By...
Candida bloodstream infections (CBI) are one of the most common nosocomial globally, and they account for a high mortality rate. The increasing global prevalence drug-resistant strains has also been posing challenge to clinicians. In this study, we comprehensively evaluated biofilm formation production hemolysin proteinase 63 CBI isolates derived from hospital setting in Hong Kong as well their antifungal susceptibility both presence absence human serum, using standard methodology. C....
TRPA1 (transient receptor potential ankyrin 1) is a nonselective Ca2+-permeable cation channel, which was originally cloned from human lung fibroblasts (HLFs). TRPA1-mediated Ca2+ entry evoked by exposure to several chemicals, including allyl isothiocyanate (AITC), and protective effect of activation in the development cardiac fibrosis has been proposed. Yet function TGF-β1 (transforming growth factor-β1)-driven fibroblast-to-myofibroblast differentiation pulmonary remains elusive....
Interstitial macrophages (IMs) are essential for organ homeostasis, inflammation, and autonomous immune response in lung tissues, which achieved through polarization to a pro-inflammatory M1 an M2 state tissue repair. Their remote parenchymal localization low counts, however, limiting factors their isolation molecular characterization of specific role during inflammation. We isolated viable murine IMs sufficient quantities by coculturing them with stromal cells analyzed mRNA expression...
Abstract Low-frequency sinusoidal current applied to human skin evokes local axon reflex flare and burning pain, indicative of C-fibre activation. Because topical cooling works well as a analgesic, we examined the effect on pain ratings rectangular profiles constant stimulation. Unexpectedly, increased upon from 32 18°C. To explore this paradoxical observation, effects responses stimulation with were determined in ex vivo segments mouse sural pig saphenous nerve. As expected by...
Extramedullary plasmactyoma is the solitary, soft tissue form of plasma cell neoplasm but lack defining features medullary or multiple myeloma. The diagnosis difficult to make in routine practice setting due morphological and immunohistochemical overlap with plasmablastic lymphoma. We report a case extramedullary plasmacytoma 52-year-old mandibular lingual gingiva discuss its differential from gingival mass regressed primary radiotherapy.
Candida albicans is a commensal polymorphic and opportunistic fungus, which usually resides as small community in the oral cavities of majority humans. The latter eco-system presents this yeast varied opportunities for mutualistic interactions with other cohabitant bacteria, that synergizes its persistence pathogenicity. Collectively, these communities live within complex plaque biofilms may adversely affect health increase proclivity candidiasis. proteome such myriad interkingdom are...
Abstract Transient receptor potential ankyrin 1 (TRPA1) is a non-selective Ca 2+ permeable cation channel, which was originally cloned from human lung fibroblasts (HLFs). TRPA1-mediated entry evoked by exposure to several chemicals, including allyl isothiocyanate (AITC), and protective effect of TRPA1 activation in the development cardiac fibrosis has been proposed. Yet, function transforming growth factor β1 (TGF-β1)-driven fibroblast myofibroblast differentiation pulmonary remains elusive....
Abstract Ischemia-reperfusion(IR)-induced edema formation can be mimicked ex-vivo in isolated perfused mouse lungs (IPL). Here we show enhanced transient receptor potential vanilloid 4 (TRPV4)-deficient (TRPV4-/-) IPL compared to wild-type (WT) controls response IR, indicating a protective role of TRPV4 maintain the alveolar epithelial barrier. By immunohistochemistry, mRNA profiling or electrophysiological analysis detected bronchial epithelium, type I (ATI) and II (ATII) cells. Genetic...
Ischemia‐reperfusion‐induced edema formation as one of the most common and significant causes morbidity mortality after lung transplantation can be mimicked ex‐vivo in isolated perfused mouse lungs (IPL). Transient receptor potential vanilloid 4 (TRPV4) is a non‐selective cation channel expressed endothelium where increased activity has been shown to compromise endothelial barrier function. Here we show enhanced TRPV4‐deficient (TRPV4−/−) IPL compared wild‐type (WT) controls response...