A5074539161- Pregnancy and preeclampsia studies
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Innovative Microfluidic and Catalytic Techniques Innovation
- Essential Oils and Antimicrobial Activity
- Birth, Development, and Health
- Entomopathogenic Microorganisms in Pest Control
- Reproductive System and Pregnancy
- Advanced Chemical Sensor Technologies
- Forest Insect Ecology and Management
- Mycotoxins in Agriculture and Food
- Indoor Air Quality and Microbial Exposure
- Epigenetics and DNA Methylation
- Plant Pathogens and Fungal Diseases
Universität Innsbruck
2022-2025
Tyrolean Cancer Research Institute
2022
Otto-von-Guericke University Magdeburg
2017-2021
University Hospital Leipzig
2020-2021
Leipzig University
2020-2021
Abstract Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of response. For first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to formation non-toxic volatile metabolite, acetone, which potentially applied monitor humans. In vitro biotransformation HepG2 cells overexpressing CYP3A4, CYP2D6 or CYP2C9 was...
The present study aims to explore the potential application of proton transfer reaction time-of-flight mass spectrometry (PTR-ToF-MS) for real-time monitoring microbial volatile organic compounds (MVOCs). This investigation can be broadly divided into two parts. First, a selection 14 MVOCs was made based on previous research that characterized MVOC emissions
Abstract Placental insufficiency jeopardizes prenatal development, potentially leading to intrauterine growth restriction (IUGR) and stillbirth. Surviving fetuses are at an increased risk for chronic diseases later in life. IUGR is closely linked with altered trophoblast placental differentiation. However, due a paucity of mechanistic insights, suitable biomarkers specific therapies lacking. The transcription factor p45 NF-E2 (nuclear erythroid derived 2) has been recently found regulate...
Microbial volatile organic compounds (MVOCs) are thought to play a key role in the interactions between mycoparasitic fungi, such as biocontrol agent Trichoderma atroviride (T. atroviride), and their environment. However, analysis of MVOC emissions from fungal samples is challenging because low analyte concentrations, typically ppbV-range, complex chemical nature biological samples. In recent study using proton transfer reaction-time flight-mass spectrometry (PTR-ToF-MS) determine T....
Procoagulant extracellular vesicles (EV) and platelet activation have been associated with gestational vascular complications. EV-induced platelet-mediated placental inflammasome has shown to cause preeclampsia-like symptoms in mice. However, the effect of EV-mediated thrombo-inflammation on trophoblast differentiation remains unknown. Here, we identify that thrombo-inflammatory pathway modulates morphology differentiation. EVs platelets reduce syncytiotrophoblast while increasing giant...
The use of volatile biomarkers in exhaled breath as predictors to individual drug response would advance the field personalised medicine by providing direct information on enzyme activity. This result enormous benefits, both for patients and healthcare sector. Non-invasive tests also gain a high acceptance patients. Towards this goal, differences metabolism resulting from extensive polymorphisms major group drug-metabolizing enzymes, cytochrome P450 (CYP) family, need be determined...
Trichoderma is a fungal genus comprising range of mycoparasitic species which have found widespread use as biofertilizers and biofungicides in agriculture to protect plants against broad plant pathogens. While the exact mechanisms behind Trichoderma-based biocontrol are not yet fully understood, microbial volatile organic compounds (MVOCs) thought play key role. Here, we employed proton-transfer-reaction time-of-flight mass spectrometry (PTR-ToF-MS) for identification online monitoring total...
Scientific Research Question: Thrombomodulin (TM) deficiency causes tissue-factor initiated thrombin generation, maternal platelet-activation and embryonic lethality in mice. However, the mechanism remains poorly understood. We have recently shown that procoagulant extracellular vesicles (EVs) activate platelets, which results purinergic receptor mediated inflammasome activation trophoblast subsequently preeclampsia (PE). therefore investigated whether this EV-mediated thrombo-inflammatory...
Scientific Research Question: Thrombomodulin (TM) deficiency causes tissue-factor initiated thrombin generation, maternal platelet-activation and embryonic lethality in mice. However, the mechanism remains poorly understood. We have recently shown that procoagulant extracellular vesicles (EVs) activate platelets, which results purinergic receptor mediated inflammasome activation trophoblast subsequently preeclampsia (PE). therefore investigated whether this EV-mediated thrombo-inflammatory...