We investigated the degradation of device reliability due to Negative Bias Temperature Instability (NBTI) PMOSFET with ultrathin gate oxide. It was experimentally demonstrated that chemical reactions at oxide/substrate interface and/or diffusion hydrogen related species are major cause NBTI. also found nitridation oxide enhances In order suppress NBTI, density terminated silicon bond needs be minimized. Thus, concentration nitrogen in thin has optimized terms reduction

Two kinds of the fat-soluble dye, Sudan black and red, were intravenously injected on alternate days into layers aged from 5 to 23 months study growth pattern ovarian follicle in relation aging. Results indicated: 1) length rapid period showed a tendency shorten during 11 months, then lengthen 15 age; 2) there was continuous increase follicular volume at ovulation with progress 3) rate (degree curvature line calculated each follicle) low increased 8 remained constant thereafter; 4) first...

An artificial metalloenzyme (ArM) utilizing a human serum albumin (HSA) scaffold exhibits remarkable catalytic stability due to the presence of center within deep hydrophobic pocket, demonstrating potential in vivo applicability for disease treatment via prodrug activation strategy. Additionally, development latent catalyst is an important consideration therapy suppress undesired prodrugs. In this study, we developed activity control system using bispecific metallopeptide, composed CpRu...

Chicken or ovine gonadotropins were injected into laying hens at 12 h after the C1 oviposition (approximately 14 before C3 ovulation). Plasma and walls of 3 largest follicles taken from within period 15–90 min hormone injection to be assayed for progesterone (P) estrogen (E) by RIA. P concentrations in plasma follicles, particularly one, rose sharply during first 30 chicken anterior pituitary (CP) LH (oLH) reached maximum min. follicular sustained a high level 90 CP injection, while levels...

Anterior pituitary and blood plasma were collected from 285 laying hens with regular clutch sequences at 8 sampling times within the period ovulation of second to third egg clutch. Plasma concentrates used for assay material obtained by a procedure based on cold acetone fractionation method. A modification Steelman-Pohley was found adequate estimate FSH potency homogenates or hens. Using NIH-FSH-S4 as standard, 2×2 design employed in all assays measure levels during cycle. Two peaks 3 when...

To analyze characteristics of follicular rapid growth patterns in relation to clutch length and egg position various lengths, Sudan black red were alternately injected intravenously into laying hens. The average period tended decrease as size increased, this was accompanied by an increase rate. number growing follicles the total amount daily yolk deposition layers with short clutches less than exhibiting long clutches. advanced 2 6 eggs. Follicular volume at ovulation also be terminal (Ct) 5...

To demonstrate time of transformation ovarian follicles from the resting stage to rapid growth phase, Sudan black in ethanol was intravenously injected into laying hens, and 4 hr later red water same hens; hens were killed after last injection for observation follicles. Injections made at various times during an ovulatory cycle. In additional experiment, hourly yolk deposition dark period (1900 0500 hr) compared with that light period. Follicular occurred a high frequency within 8 14...

Summary. The total gonadotrophic activities of the anterior pituitary glands and blood plasma hens, Gallus domesticus, during moulting period were estimated using assay method based on weight increase chick testis. in both hens four groups classified according to progress moult significantly higher than those laying hens. Nevertheless, no detectable level serum vitellin a completely regressed ovary found Anterior assayed for their fsh lh by use hcg augmentation or ovarian ascorbic acid...

An LSI CODEC, an multiplexed digital filter, and compandor are developed for telephone PCM AD/DA conversion. The total chip count is 1.56 chips per channel. single-chip interpolative CODEC operates at a 32 kHz sampling rate with 12-bit linear code input/output, implemented in phosphorus buried emitter IIL process without the need component value trimming. filter four-channel both transmitting receiving directions. It compactly fabricated combinatorial configuration 5 /spl mu/m NMOS process....

Abstract Devitalized, neonatal, rat calvariae incubated in a buffered solution release Ca2+ and P1 during the first day into medium until levels reach 1.2 mM 2.6 mM, respectively. Thereafter gradually decrease to stabilize by fifth at 0.5 2 mM. Comparison of these solubility changes with those known calcium phosphate salts suggests that calvarial is controlled mixture impure, soluble, apatite precursors, which cell death transform an impure apatite. Increasing concentrations Mg2+ increased...

The cholinergic innervation of the choroid as disclosed by acetylcholi-nesterase technique has been studied in several albitonic and pigmented mammals. Acetyl-cholinesterase-containing nerve fibers are commonly observed albinotic species either surrounding choroidal blood vessels or freely running stroma; occasionally a few seen choriocapillaris. A far lesser density acetylcholinesterase-positive is species, that inversely related to pigmentation. combination physical masking physicochemical...

Methods for producing drugs directly at the cancer site, particularly using bioorthogonal metal catalysts, are being explored to mitigate side effects of therapy. Albumin-based artificial metalloenzymes (ArMs) catalyze reactions in living mice while protecting catalyst hydrophobic pocket. Here, we describe situ preparation and application biocompatible tumor-targeting ArMs circulating albumin, which is abundant bloodstream. The ArM was formed blood albumin through intravenous injection...

Abstract Methods for producing drugs directly at the cancer site, particularly using bioorthogonal metal catalysts, are being explored to mitigate side effects of therapy. Albumin‐based artificial metalloenzymes (ArMs) catalyze reactions in living mice while protecting catalyst hydrophobic pocket. Here, we describe situ preparation and application biocompatible tumor‐targeting ArMs circulating albumin, which is abundant bloodstream. The ArM was formed blood albumin through intravenous...

開業後48年が経過した東海道新幹線のRC構造物は，これまで適正に維持管理が実施されている。しかしながら，継続的な実態調査の結果，2000年から実施されている中性化抑止のための表面保護工の一部の部位には，列車通過に伴う繰返し荷重によりひび割れが再発生しており，経年による中性化の進行が懸念される。大動脈である東海道新幹線のRC構造物を将来にわたり健全に維持するため，これまで抜本的な中性化対策の技術開発に取り組んできた。今回維持・強化対策として，新たな全断面修復工法（鋼板巻き）を開発したので，その実験，解析内容，ならびに本線での施工結果と構造形式の検討内容について報告する。

In Brief This is a report of 66-year-old woman presenting with cervical intraepithelial neoplasia grade 3 extending to the entire endometrium.