A5012842247- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Indoor Air Quality and Microbial Exposure
- Eicosanoids and Hypertension Pharmacology
- Drug Transport and Resistance Mechanisms
- Medical and Biological Ozone Research
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- nanoparticles nucleation surface interactions
- Microbial Inactivation Methods
- Fatty Acid Research and Health
- Cystic Fibrosis Research Advances
- Chemical Reactions and Isotopes
- Noise Effects and Management
- Inhalation and Respiratory Drug Delivery
- Advanced Glycation End Products research
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Heavy Metal Exposure and Toxicity
- Pharmacological Effects of Natural Compounds
- Respiratory and Cough-Related Research
- Adipose Tissue and Metabolism
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
University Hospital Münster
2025
University of Oulu
2024
University of Southern California
2007-2009
Essen University Hospital
2003
National Institutes of Health
1997-1999
National Cancer Institute
1997-1999
Chronic administration of peroxisome proliferators to mice and rats results in hepatomegaly ultimately carcinogenesis. The mechanism underlying the carcinogenic effect nongenotoxic is not well understood. To determine whether carcinogenesis receptor mediated, we evaluated prototypical proliferator Wy-14,643 on replicative DNA synthesis PPAR alpha-null mouse line. Male (F4, Sv/129 ter) both genotypes (+/+) (-/-) were fed either a control diet or one containing 0.1% for 1 week, 5 weeks, 11...
The aryl hydrocarbon receptor (AhR) mediates many of the biological effects 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and transcriptional activation genes encoding a number xenobiotic metabolizing enzymes. Prenatal exposure mice to TCDD causes severe alterations in embryo fetal development, including hydronephrosis cleft palate. However, mechanisms underlying these are unclear. In this work, teratogenicity AhR-null was evaluated determine if effect is mediated by AhR. Homozygous wild-type...
Peroxisome proliferator-activated receptor alpha (PPAR alpha) mediates the effects of foreign chemical peroxisome proliferators on liver and kidney, including induction peroxisomal, mitochondrial, microsomal enzymes involved in beta-oxidation fatty acids. However, role this proliferative endogenous steroid dehydroepiandrosterone (DHEA) is not known. DHEA-3 beta-sulfate fd(DHEA-S) shown to induce a response rats vivo at dose which DHEA much less active, consistent with cultured hepatocyte...
<h3>Background:</h3> The interrelationships between air pollution, lung function and the incidence of childhood asthma have yet to be established. A study was undertaken determine whether is associated with new onset this relationship varies by exposure ambient pollutants. <h3>Methods:</h3> cohort children aged 9–10 years without or wheeze at entry were identified from Children's Health Study followed for 8 years. participants resided in 12 communities a wide range pollutants that measured...
Rationale: The mucoid phenotype of Staphylococcus aureus is caused by adaptation. Excessive biofilm formation associated with a protective effect for S. was observed in isolates from respiratory samples people cystic fibrosis (pwCF). However, there little knowledge about the prevalence pwCF and potential association CF lung disease. Methods: A prospective multicenter study conducted (cross-sectional longitudinal). Specimens case report forms were sent to central laboratory characterization...
<h3>Background</h3> Inducible nitric oxide (NO) synthase (iNOS, encoded by <i>NOS2A</i>) produces NO in response to environmental stimuli, which can result nitrosative stress. Because stress affects respiratory health, it was hypothesised that variants <i>NOS2A</i> are associated with asthma incidence and lung function growth during adolescence. <h3>Methods</h3> In this prospective study, spirometric testing performed at school a presence or absence of ascertained annually questionnaire...
This paper reviews studies on the adverse health effects of exposure to metals, using arsenic and cadmium as examples. The carcinogenic potential has been studied in various settings. Inhalation is clearly related development lung cancer (copper) smelting arsenical pesticide manufacturing, also heavily exposed wine merchants who had an additional source by ingestion. Animal have shown be a carcinogen, while study Thun et al. provides best evidence date that inhaled CdO particles may human...
Background: Immunotherapy appears to be a potent treatment against Alzheimer's disease (AD), but the mechanisms underlying neural-immune interaction are still not known. Methods: Here, we determined cell death and distribution of lymphocyte subsets peripheral blood mononuclear cells (PBMC) in AD aging, e.g. T (CD4+CD3+, CD8+CD3+), B (CD19+) NK (CD16++CD56+) cells. Results: Increased apoptosis was found CD4+ AD, while aging all were affected. The expression anti-apoptotic Bcl2 correlated with...
Blockade of activin 2 receptor (ACVR2) signaling has been shown to improve insulin sensitivity and aid in weight loss. Inhibition ACVR2 restores cardiac function multiple heart failure models. However, its potential the treatment obesity-related cardiometabolic disease remains unknown. Here, we investigated targeting manifested with metabolic dysfunction-associated steatotic liver (MASLD).
The mechanisms underlying phenacetin-induced toxicity and carcinogenicity are not clear. In particular, it is known whether these effects mediated by metabolic activation of the drug. CYP1A2 to metabolize phenacetin in vitro. To determine role this enzyme vivo, was examined Cyp1a2-null mice (that lack CYP1A2). Six- 8-week-old wild type (+/+) or null (-/-) were fed either a control diet, one containing 1.25% phenacetin, ad libitum for up 67 weeks. Representative groups after 36, 48, 58, weeks...