A5018947132- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Protein Kinase Regulation and GTPase Signaling
- Receptor Mechanisms and Signaling
- Cell death mechanisms and regulation
- Cardiovascular Function and Risk Factors
- Nuclear Receptors and Signaling
- Diet, Metabolism, and Disease
- Trace Elements in Health
- Enzyme function and inhibition
- Neuroscience and Neuropharmacology Research
- Nitric Oxide and Endothelin Effects
- Estrogen and related hormone effects
- Ion Transport and Channel Regulation
- Heart Failure Treatment and Management
- Diet and metabolism studies
- Signaling Pathways in Disease
- Vitamin C and Antioxidants Research
- Fatty Acid Research and Health
- Heavy Metal Exposure and Toxicity
- Cannabis and Cannabinoid Research
- Advanced Nanomaterials in Catalysis
- Lanthanide and Transition Metal Complexes
Centro de Investigaciones Cardiovasculares
2009-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2024
Universidad Nacional de La Plata
2009-2024
Angiotensin (Ang) II-induced apoptosis was reported to be mediated by different signaling molecules. Whether these molecules are either interconnected in a single pathway or constitute and alternative cascades which Ang II exerts its apoptotic action, is not known.To investigate cultured myocytes from adult cat rat, 2 species has opposite inotropic effects, the cascade involved apoptosis.Ang (1 micromol/L) reduced cat/rat viability approximately 40%, part, because of (TUNEL/caspase-3...
The objective of this study was to establish whether 1) hyperactivity renin-angiotensin-aldosterone system (RAAS) produces apoptosis in early stages cardiac disease; and 2) Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is involved these apoptotic events. Two models hypertrophy were used at an stage disease: spontaneously hypertensive rats (SHR) isoproterenol-treated (Iso-rats). At 4 mo, SHR showed blood pressure, aldosterone serum levels, as RAAS activity index, left ventricular...
Spontaneously hypertensive rat (SHR) constitutes a genetic model widely used to study the natural evolution of heart disease. Ca2+-handling alterations are known occur in SHR. However, putative modifications proteins during progression failure (HF) not well established. Moreover, role apoptosis SHR is controversial. We investigated intracellular Ca2+, and vs. control Wistar rats (W) from 3 15 months (mo). Changes associated with transition HF (i.e. lung edema decrease midwall fractional...
Introduction: It has been demonstrated the dysregulation of cardiac endocannabinoid system in cardiovascular diseases. Thus, modulation this through administration phytocannabinoids present medicinal cannabis oil (CO) emerges as a promising therapeutic approach. Furthermore, exhibit potent antioxidant properties, making them highly desirable treatment pathologies, such hypertension-induced hypertrophy (CH).