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Peyton McClelland

ORCID: 0009-0009-7671-8506
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A5093879945
Research Areas
  • Genetic factors in colorectal cancer
  • Genomics and Rare Diseases
  • Genetic Associations and Epidemiology

McGill University
 2024

 A cost-effective sequencing method for genetic studies combining high-depth whole exome and low-depth whole genome
OPENALEX - Publications 
Claude Bhérer Robert Eveleigh Katerina Trajanoska Janick St-Cyr Antoine Paccard and 16 more Praveen Nadukkalam Ravindran Elizabeth Caron Nimara Bader Asbah Peyton McClelland Clare Wei Iris Baumgärtner Marc Schindewolf Yvonne Döring Danielle Perley François Lefebvre Patricia Lepage Mathieu Bourgey Guillaume Bourque Jiannis Ragoussis Vincent Mooser Daniel Taliun

Abstract Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in coding and non-coding DNA regions helps elucidate genetic underpinnings human health diseases. Yet, due to prohibitive cost WGS, most large-scale association studies use genotyping arrays or whole exome (WES). Here we propose a cost-effective method which call “Whole Exome Genome Sequencing” (WEGS), that combines low-depth WGS WES with up 8 samples pooled sequenced simultaneously...

10.1038/s41525-024-00390-3 article EN cc-by npj Genomic Medicine 2024-02-07
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