A5090312417- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Renal and related cancers
- Genetic diversity and population structure
- Plant and animal studies
- Species Distribution and Climate Change
- Fish Ecology and Management Studies
- Animal Behavior and Reproduction
- Environmental DNA in Biodiversity Studies
- Evolution and Genetic Dynamics
- Physiological and biochemical adaptations
- Aquatic Invertebrate Ecology and Behavior
- Genetic Associations and Epidemiology
- Marine Bivalve and Aquaculture Studies
- Evolutionary Game Theory and Cooperation
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Ecology and Vegetation Dynamics Studies
- Radiomics and Machine Learning in Medical Imaging
- Genetic and phenotypic traits in livestock
- Plant Water Relations and Carbon Dynamics
- Plant responses to elevated CO2
- Wildlife Ecology and Conservation
- Plant Physiology and Cultivation Studies
- Greenhouse Technology and Climate Control
McGill University
2014-2024
McGill Genome Centre
2019-2024
Université du Québec à Montréal
2023
University of Neuchâtel
2010-2016
Climate change is predicted to lead increased average temperatures and greater intensity frequency of high low temperature extremes, but the evolutionary consequences for biological communities are not well understood. Studies adaptive evolution tolerance have typically involved correlative analyses natural populations or artificial selection experiments in laboratory. Field required provide estimates timing strength selection, enhance understanding genetics adaptation yield insights into...
Evolutionary biologists have long trained their sights on adaptation, focusing the power of natural selection to produce relative fitness advantages while often ignoring changes in absolute fitness. Ecologists generally taken a different tack, abundance and ranges that reflect Uniting these perspectives, we articulate various causes maladaptation review numerous examples occurrence. This indicates is reasonably common from both yet contrasting ways. That is, can appear strong perspective,...
Evolutionary approaches are gaining popularity in conservation science, with diverse strategies applied efforts to support adaptive population outcomes. Yet differ the type of outcomes they promote as goals. For instance, based on genetic or demographic rescue implicitly target states whereas utilizing transgenerational plasticity evolutionary processes. These two goals somewhat polar: state optimize current fitness, which should reduce phenotypic and/or variance, reducing adaptability...
Abstract Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in coding and non-coding DNA regions helps elucidate genetic underpinnings human health diseases. Yet, due to prohibitive cost WGS, most large-scale association studies use genotyping arrays or whole exome (WES). Here we propose a cost-effective method which call “Whole Exome Genome Sequencing” (WEGS), that combines low-depth WGS WES with up 8 samples pooled sequenced simultaneously...
Abstract Purpose: Patients with resected localized clear-cell renal cell carcinoma (ccRCC) remain at variable risk of recurrence. Incorporation biomarkers may refine prediction and inform adjuvant treatment decisions. We explored the role tumor genomics in this setting, leveraging largest cohort to date ccRCC tissues subjected targeted gene sequencing. Experimental Design: The somatic mutation status 12 genes was determined 943 cases from a multinational patients, associations outcomes were...
The threespine stickleback is an important species in the study of parallel evolution. However, evidence for evolution, and genetic phenotypic levels, has largely come from west coast North America parts southern Europe. Here, we use RAD-sequencing pooled samples to marine-freshwater differentiation Atlantic Canada test Our results show considerable heterogeneity among populations, with some freshwater populations showing high degree allele frequency divergence relative marine ones....
Despite aggressive upfront treatment in glioblastoma (GBM), recurrence remains inevitable for most patients. Accumulating evidence has identified hypermutation induced by temozolomide (TMZ) as an emerging subtype of recurrent GBM. However, its biological and therapeutic significance yet to be described.We combined GBM patient derive stem cells (GSCs) from tumors following TMZ explore response hypermutant non-hypermutant emergent phenotypes the immune relevance states vivo.Hypermutation...
Abstract Parallel evolution is considered strong evidence for natural selection. However, few studies have investigated the process of parallel selection as it plays out in real time. The common approach to study historical signatures populations already well adapted different environments. Here, document under conditions, we six threespine stickleback ( Gasterosteus aculeatus ) inhabiting bar‐built estuaries that undergo seasonal cycles environmental changes. Estuaries are periodically...
Abstract The evolutionary consequences of temporal variation in selection remain hotly debated. We explored these by studying threespine stickleback a set bar‐built estuaries along the central California coast. In most years, heavy rains induce water flow strong enough to break through isolating sand bars, connecting streams ocean. New bars typically re‐form within few weeks or months, thereby re‐isolating populations estuaries. These breaching events cause severe and often extremely rapid...
Species distribution limits are hypothesized to be caused by small population size and limited genetic variation in ecologically relevant traits, but earlier studies have not evaluated multivariate phenotypes. We asked whether populations at the latitudinal edges of altered quantitative architecture traits compared with midlatitude populations. calculated measures evolutionary potential nine Arabidopsis lyrata spanning range species eastern midwestern North America. Environments extremes...
Abstract The repeatability of adaptive radiation is expected to be scale-dependent, with determinism decreasing as greater spatial separation among “replicates” leads their increased genetic and ecological independence. Threespine stickleback (Gasterosteus aculeatus) provide an opportunity test whether this expectation holds for the early stages radiation—their diversification in freshwater ecosystems has been replicated many times. To better understand that radiation, we examined influence...
Abstract Microhabitat heterogeneity can lead to fine‐scale local adaptation when gene flow is restricted, which may be important for the maintenance of genetic variation within populations. This study tested whether microhabitat was associated with trait differences in a population A rabidopsis lyrata and studied its impact on variance–covariance ( G ) matrix. Maternal seed families were collected from dune tops bottoms, two microhabitats known vary significantly water availability. In...
Species distribution models (SDMs) are widely used to predict range shifts but could be unreliable under climate change scenarios because they do not account for evolution. The thermal physiology of a species is key determinant its and thus incorporating trait evolution into SDMs might expected alter projected ranges. We identified genetic basis physiological behavioural traits that evolve in response temperature natural populations threespine stickleback (Gasterosteus aculeatus). Using...
Ecosystem size is known to influence both community structure and ecosystem processes. Less about the evolutionary consequences of size. A few studies have shown that shapes evolution trophic diversity by shaping habitat heterogeneity, but effects on antipredator trait not been explored. may impact predator presence (larger ecosystems longer food chains) complexity more diverse structure). We tested these using threespine stickleback from bar‐built estuaries along Central Coast California....
Renal cell carcinoma (RCC) is known for its variable clinical behavior and outcome, including heterogeneity in developing relapse or metastasis. Recent data highlighted the potential of somatic mutations as promising biomarkers risk stratification RCC. Likewise, analysis circulating tumor DNA (ctDNA) such informative (liquid biopsy) considered an important advance precision oncology RCC, allowing to monitor molecular disease evolution real time. However, our knowledge about utility ctDNA RCC...
ABSTRACT The repeatability of adaptive radiation is expected to be scale dependent, with determinism decreasing as greater spatial separation among “replicates” leads their increased genetic and ecological independence. Threespine stickleback ( Gasterosteus aculeatus ) provide an opportunity test whether this expectation holds for the early stages - diversification in freshwater ecosystems has been replicated many times. To better understand that radiation, we examined influence geographic...
ABSTRACT Biological invasions have caused the loss of freshwater biodiversity worldwide. The interplay between adaptive responses and demographic characteristics populations impacted by is expected to be important for their resilience, but interaction these factors poorly understood. gastropod Amnicola limosus native Upper St. Lawrence River distributed along a water calcium concentration gradient within which high‐calcium habitats are an invasive predator fish ( Neogobius melanostomus ,...
0 Abstract Whole genome sequencing (WGS) at high-depth (30X) allows the accurate discovery of variants in coding and non-coding DNA regions helps elucidate genetic underpinnings human health diseases. Yet, due to prohibitive cost WGS, most large-scale association studies use genotyping arrays or whole exome (WES). Here we propose a novel, cost-effective method, which call “Whole Exome Genome Sequencing” (WEGS), that combines low-depth WGS WES with up 8 samples pooled sequenced simultaneously...
Abstract Parallel evolution is considered strong evidence for natural selection. However, few studies have investigated the process of parallel selection as it plays out in real time. The common approach to study historical signatures populations already well adapted different environments. Here, document action under conditions, we six threespine stickleback ( Gasterosteus aculeatus ) inhabiting bar-built estuaries that undergo seasonal cycles environmental changes. Estuaries are...
Abstract Species distribution models (SDMs) are widely used to predict range shifts but could be unreliable under climate change scenarios because they do not account for evolution. The thermal physiology of a species is key determinant and thus incorporating trait evolution into SDMs might expected alter projected ranges. We identified genetic basis physiological behavioural traits that evolve in response temperature natural populations threespine stickleback (Gasterosteus aculeatus). Using...
Biological invasions have caused the loss of freshwater biodiversity worldwide. The interplay between adaptive responses and demographic characteristics is expected to be important for resilience populations biological invasions, but interaction these factors poorly understood. native gastropod Amnicola limosa distributed along spatial variation in impact from an invasive molluscivorous fish (Neogobius melanostomus), as well calcium concentrations, limiting distribution this invader...
<p>Supplementary Methods</p>
<p>Disease-Free Survival outcomes amongst genomic groups when applied to the 247 VHL mutated ccRCCs from TCGA dataset</p>