A5014222498- Amyotrophic Lateral Sclerosis Research
- Prion Diseases and Protein Misfolding
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Pesticide and Herbicide Environmental Studies
- Neurogenetic and Muscular Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Apelin-related biomedical research
- Diet and metabolism studies
- Pesticide Exposure and Toxicity
- Dietary Effects on Health
- Hormonal Regulation and Hypertension
University of Michigan–Ann Arbor
2023-2025
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes hypermetabolism—both prognostic of progression survival. The cross‐sectional ALS has been characterized, but longitudinal correlations to functional decline are lacking. Methods We longitudinally evaluated metabolomes from plasma terminal postmortem spinal cord brain motor cortex tissue. constructed 3 models. A...
Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurogenerative disease caused by combined genetic susceptibilities and environmental exposures. Identifying validating these exposures are of paramount importance to modify risk. We previously reported that persistent organic pollutants (POPs) associate with ALS risk survival aimed replicate findings in new cohort. Method Participants without recruited Michigan provided plasma samples for POPs analysis isotope dilution...
An adverse social exposome negatively affects many diseases, but its association with amyotrophic lateral sclerosis (ALS) survival is unknown. This study examined the between measure Area Deprivation Index (ADI) and ALS survival. a retrospective analysis of patients at University Michigan Pranger Clinic diagnosed after January 1, 2012. Extracted data included age, sex, race, residential address, disease characteristics, National ADI ranking was assigned to each patient's geocoded address....
Abstract INTRODUCTION Metabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer's disease (AD). Immune system dysregulation inflammation, particularly microglial mediated, may underlie this risk, but mechanisms remain unclear. METHODS Using a high‐fat diet‐fed (HFD) model, we assessed longitudinal metabolism cognition, terminal inflammation brain spatial transcriptomics. Additionally,...
Abstract Patients with type 2 diabetes often develop the microvascular complications of diabetic kidney disease (DKD) and peripheral neuropathy (DPN), which decrease quality life increase mortality. Unfortunately, treatment options for DKD DPN are limited. Lifestyle interventions, such as changes to diet, have been proposed non‐pharmacological preventing or improving DPN. However, there no reported studies simultaneously evaluating therapeutic efficacy varying dietary interventions in a...
ABSTRACT Diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN) are common complications of type 1 (T1D) 2 (T2D) diabetes. However, the mechanisms underlying pathogenesis these unclear. In this study, we optimized a streptozotocin-induced db/+ murine model T1D compared it to our established db/db T2D mouse same C57BLKS/J background. Glomeruli sciatic nerve transcriptomic data from mice were analyzed by self-organizing map differential gene expression analysis. Consistent with...
Environmental exposures impact amyotrophic lateral sclerosis (ALS) risk and progression, a fatal progressive neurodegenerative disease. Better characterization of these is needed to decrease disease burden.
The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic and environmental factors. This study investigates associations between metal measures in plasma urine, ALS risk survival exposure sources.
Abstract Type 2 diabetes (T2D) is a complex chronic metabolic disorder characterized by hyperglycemia because of insulin resistance. Diabetes with may alter brain metabolism, including glucose and neurotransmitter levels; however, detailed, longitudinal studies alterations in T2D are lacking. To shed insight, here, we the consequences poorly controlled on neurochemical profiles that reflect both humans animal models T2D. Using vivo 1 H magnetic resonance spectroscopy, quantified 12...