A5020124826- Boron Compounds in Chemistry
- melanin and skin pigmentation
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Melanoma and MAPK Pathways
- Radiation Therapy and Dosimetry
- RNA regulation and disease
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Skin Protection and Aging
- Immunotherapy and Immune Responses
- Heparin-Induced Thrombocytopenia and Thrombosis
- Biochemical Analysis and Sensing Techniques
- Photochromic and Fluorescence Chemistry
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- Computational Drug Discovery Methods
- Radiation Detection and Scintillator Technologies
- Blood Coagulation and Thrombosis Mechanisms
- Atrial Fibrillation Management and Outcomes
- Dye analysis and toxicity
- Organoboron and organosilicon chemistry
- bioluminescence and chemiluminescence research
- Ultrasound and Hyperthermia Applications
University of Oklahoma Health Sciences Center
2024-2025
University of Virginia
2025
Octapharma (Austria)
2025
BrightPath Biotherapeutics (Japan)
2021
Shinshu University
1992-2000
Kobe University
1980-1999
Fukuda Denshi (Japan)
1999
Tohoku University
1999
Kyoto University
1999
Honda (Japan)
1992-1999
Research Articles| October 27 2009 Oncogenic Differentiation of the Intraepidermal Eccrine Sweat Duct: Poroma, Poroepithelioma and Porocarcinoma Subject Area: Dermatology , Immunology Allergy Y. Mishima; Mishima Departments (Chairman: H. Pinkus, M. D.), Wayne State University School Medicine, Detroit, Veterans Administration Hospital, Allen Park, Michigan Search for other works by this author on: This Site PubMed Google Scholar S. Morioka Dermatologica (1969) 138 (4): 238–250....
Benign and malignant cellular blue nevi have been studied cytopathologically, enzymatically electron microscopically. Scarcely pigmented, Schwann-cell-like, spindle-shaped cells which characterize types of nevus found to possess tyrosinase activity can form premelanosome systems. These undergo melanization, at least in vitro, the vesicles cisternae smooth endoplasmic reticulum vicinity Golgi apparatus as well intermediate premelanosomes. It is concluded that characteristic represent a...
A treatment regimen for boron neutron capture therapy of malignant melanomas is described using 10B-paraboronophenylalanine as the tumor-targeting compound. As a therapeutic dose, we adopted maximum tolerable dose skin regardless tumor 10B concentration. In practice, fluence should be decided prior to starting irradiation. For this purpose, kinetics concentration in blood and skin-to-blood ratios were analyzed six patients who received 170 mg/kg compound intravenously, concentrations during...
Butt, Amir L. MD, MPH; Mazzeffi, Michael A. MPH, MSc; Mishima, Yuko PhD; Tanaka, Kenichi MSc Author Information
BACKGROUND: Advances in blood conservation have reduced the need for allogeneic transfusions total knee and hip arthroplasty (TKA/THA). This study aimed to assess whether perioperative bleeding complications, including hemorrhage/hematoma, transfusions, postoperative anemia, occurred at similar rates between patients with hereditary disorders (BDs) controls. Using a national health care database, we assessed use of clotting factor concentrates (CFCs), outcomes, resource utilization. METHODS:...
We have established methods of targeting a sufficient number 10B atoms on human melanoma cells to allow selective destruction the cancer by thermal neutron irradiation. Thermal capture therapy (NCT)1–3 requires presence at least 10910B each target cell for specific killing that without injuring normal tissues.4,5 In order accumulate an adequate cells, we first created effective compound containing 12 per molecule (10B12-chlorpromazine)6,7 and 10B-dopa analogue...
To optimize the neutron dose for boron capture therapy (BNCT), boron-10 (10B) concentration kinetics of 10B-p-boronophenylalanine (BPA) were analysed in 22 melanoma patients with primary or metastatic melanomas who received BPA and subsequently underwent BNCT surgery. The blood nine receiving 179.7 ± 14.9 mg/kg increased time during intravenous infusion, peaked at end administration decreased thereafter. peak values 9.4 2.6 μg 10B/g blood, half-lives initial second components clearance 2.8...
Tyrosinase related protein (TRP)-1 and TRP-2 are known to regulate the quality of melanin, recently their potential role in inhibiting apoptosis have also been reported. To study tyrosinase, TRP-1 growth, differentiation cell death ultraviolet B (UVB) irradiated melanocytes, expression these proteins amelanotic melanotic cells was examined. Expression tyrosinase correlated with melanin content, which upregulated after repeated irradiation by low doses UVB. In contrast, activity...
(1980). Thermal Neutron Capture Therapy of Malignant Melanoma: in Vitro Radiobiological Analysis. International Journal Radiation Biology and Related Studies Physics, Chemistry Medicine: Vol. 37, No. 5, pp. 573-580.
A unique in vivo approach to assessing the concentrations of 4-[10B]borono-L-phenylalanine (L-BPA), a melanoma targeting compound for boron neutron capture therapy (BNCT), was investigated using L-BPA labelled with positron-emitting 18F (half-life = 110 min), i.e., 4-[10B]borono-2-[18F]fluoro-L-phenylalanine (L-[18F]FBPA). High uptake L-[18F]FBPA reduced slightly by competition two animal models murine B16 and melanotic Greene's No. 179 hamsters. In mice given L-BPA, 10B estimated from...
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We read with great interest the study by Mansour et al., which provided a longitudinal examination of plasma antithrombin levels during extracorporeal membrane oxygenation (ECMO) and investigated their correlation heparin responsiveness.1 The offers important clinical insights for intensivists managing ECMO; however, it merits further discussion on certain technical points.The authors' decision to utilize Liquid anti-Xa Stachrom ATIII assays quantifying was justified, given established...