A5102394496- ATP Synthase and ATPases Research
- Cancer-related gene regulation
- Mitochondrial Function and Pathology
- Sulfur Compounds in Biology
- Developmental Biology and Gene Regulation
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Cancer-related molecular mechanisms research
- Sulfur-Based Synthesis Techniques
- Organoselenium and organotellurium chemistry
- Enzyme function and inhibition
Lanzhou University
2024-2025
Nanjing Medical University
2024
Changzhou No.2 People's Hospital
2024
A fluorescence quenching mechanism using linear diselenides was proposed for the first time through a combination of intramolecular charge transfer (ICT) and Förster resonance energy (FRET).
Leveraging disulfide (-S-S-) or diselenide (-Se-Se-) units as triggers in the design of small-molecule fluorescent probes for detecting intracellular reductive species has demonstrated high efficacy. However, selenenylsulfides, which exhibit reactivity between diselenides and disulfides, remain relatively unexplored. In this work, we compare efficiency -S-S-, seleno-sulfur (-Se-S-), sulfur-selenium (-S-Se-) structural constructing thiol probes, disclose scaffold -Se-S- a versatile...
Nuclear factor erythroid 2 related (Nrf2) is closely associated with neurodegenerative diseases, and the Nrf2-mediated activation of antioxidant response elements (AREs) brings about validated strategies for treating diseases. Here, we discovered that troglitazone, a clinical medication diabetes mellitus, could serve as Nrf2 activator to rescue neuronal damages both in vitro vivo. The mechanism troglitazone action involves binding kelch-like ECH-associated protein 1 (Keap1) Nrf2. This...
Aerobic glycolysis is a metabolic reprogramming of tumor cells that essential for sustaining their phenotype fast multiplication by continuously supplying energy and mass. Pyruvate kinase M2 (PKM2) has vital role in this process, which given it high interest as target anticancer drug development. With potent toxicity to many types cancer cells, polyphyllin II (PP2), steroidal saponin isolated from the herbaceous plant Rhizoma paridis, brought our attention might interfere with PKM2 activity....
Pyruvate kinase M2 (PKM2), a crucial enzyme in the glycolysis pathway, is commonly documented as being overexpressed cancer cells. Inhibiting PKM2, strategy to mitigate cell-dependent glycolysis, has demonstrated efficacy anticancer treatment. In this study, plumbagin, which was originally extracted from plant