A5102936266- Hippo pathway signaling and YAP/TAZ
- Pancreatic and Hepatic Oncology Research
- Optical Polarization and Ellipsometry
- Retinal and Macular Surgery
- Hair Growth and Disorders
- Art, Technology, and Culture
- melanin and skin pigmentation
- Oral health in cancer treatment
- Optical Systems and Laser Technology
- Infrared Target Detection Methodologies
- Epigenetics and DNA Methylation
- Image Enhancement Techniques
- Advanced Image Fusion Techniques
- Digital Games and Media
- Immune Cell Function and Interaction
- Cinema and Media Studies
- Cancer Diagnosis and Treatment
- RNA regulation and disease
- interferon and immune responses
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
Changchun University of Science and Technology
2024
University of Hong Kong
2024
Hong Kong University of Science and Technology
2024
WuXi AppTec (China)
2023-2024
First Affiliated Hospital of Wenzhou Medical University
2020-2022
Wenzhou Medical University
2020-2022
Wenzhou University
2020
Anyang Eye Hospital
2018
Cancer stemness is associated with high malignancy and low differentiation, as well therapeutic resistance of tumors including pancreatic ductal adenocarcinoma (PDAC). Fibroblast growth factors (FGFs) exert pleiotropic effects on a variety cellular processes functions embryonic stem cell pluripotency cancer via the activation four tyrosine kinase FGF receptors (FGFRs). ligands have been major component cocktail contained in stemness-inducing (CSI) organoid culture medium. Although FGF/FGFR...
Polarization imaging techniques have been effective in improving the clarity of turbid underwater images affected by water scattering. These offer valuable additional information compared to traditional methods. However, previous descattering methods mostly designed for targets with uniform distribution polarimetric characteristics. Therefore, complex polarization characteristics non-uniform when dealing such problems, parameter estimation errors can limit results image recovery. This paper...
Whereas retinal pigment epithelial (RPE) cells are known to secrete VEGF-A and VEGFR2, the functions of autocrine VEGF signaling remain unclear. Meanwhile, anti-VEGF therapies have been applied routinely treat ocular vascular diseases.The aim this study was determine in RPE evaluate consequences its interruption.The genes involved Hippo signal pathways were knocked down with siRNAs both ARPE-19 cell line human primary via transient transfection whereas overexpression VEGFR2 mediated...
YAP1 is a key mediator of the Hippo pathway capable exerting profound effect on organ size as well tumorigenesis. Alternative mRNA splicing human results in at least 8 protein isoforms that differ within 2nd WW motif and transcriptional activation domain. Methods: To investigate isoform-specific differences their expression, activity tumor-promoting function, we cloned cDNA encoding all eight isoforms. Then, examined subcellular localization, regulation properties, interactions with...
Abstract YAP1, a key mediator of the Hippo pathway, plays an important role in tumorigenesis. Alternative splicing human YAP1 mRNA results two major isoforms: YAP1‐1, which contains single WW domain, and YAP1‐2, domains, respectively. We here investigated functions underlying regulatory mechanisms isoforms context EGF‐induced epithelial‐mesenchymal transition (EMT) non‐small cell lung cancer (NSCLC). Human NSCLC lines express both YAP1‐1 YAP1‐2 isoforms—although when compared to levels are...
<h3>Background</h3> Vitiligo is an autoimmune disorder that leads to progressive destruction of skin melanocytes. caused by the infiltration endogenous autoreactive CD8 + T cells destructs melanocytes with clinical manifestations pigmentation loss. As a common acquired disease no effective treatment, global incidence about 1%, vitiligo greatly affects physiology and psychology patients. Therefore, there urgent medical need for development treatments vitiligo. Several NLRP3 inhibitors have...
<h3>Background</h3> Alopecia areata (AA) is a worldwide autoimmune disease in humans characterized by patchy and sudden hair loss without scarring. The incidence prevalence of AA are only exceeded diabetes rheumatoid arthritis. Although does not shorten life or cause physical disabilities, it still considered psychologically devastating with substantial burden. pathobiological mechanism fully understood, resulting no satisfactory universally effective clinical therapy methods preventive...