Celestine Makobe

ORCID: 0009-0009-9428-705X
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Research Areas
  • Escherichia coli research studies
  • Viral gastroenteritis research and epidemiology
  • Vibrio bacteria research studies
  • Urinary Tract Infections Management
  • Antibiotic Resistance in Bacteria
  • Pediatric Urology and Nephrology Studies
  • Bee Products Chemical Analysis
  • Antibiotic Use and Resistance
  • Burkholderia infections and melioidosis
  • Vector-borne infectious diseases
  • Child Nutrition and Water Access
  • Tuberculosis Research and Epidemiology
  • Salmonella and Campylobacter epidemiology
  • Herbal Medicine Research Studies
  • Bartonella species infections research
  • Trypanosoma species research and implications
  • Parasites and Host Interactions
  • Plant Virus Research Studies
  • Coenzyme Q10 studies and effects
  • Bacteriophages and microbial interactions
  • Gut microbiota and health
  • Probiotics and Fermented Foods
  • Enterobacteriaceae and Cronobacter Research
  • Medicinal plant effects and applications
  • Microbial infections and disease research

Jomo Kenyatta University of Agriculture and Technology
2012-2025

Goethe University Frankfurt
2015

ABSTRACT We report the genome sequences of 14 Acinetobacter phages isolated in Kenya, belonging to genera Friunavirus and Obolenskvirus . They have double-stranded DNA with sizes between 39 45 kb G + C content from 38% 39%. The genomes contain 56 93 predicted coding sequences.

10.1128/mra.01193-24 article EN Microbiology Resource Announcements 2025-02-25

Among the bacterial causes, diarrheagenic Escherichia coli (DEC) is most important etiologic agent of childhood diarrhoea and represents a major public health problem in developing countries. New evidence suggests that differences virulence among groups DEC pathotypes may be related to presence specific pathogenicity islands (PAIs).Multiplex conventional PCR assays were used identify PAIs respectively from 207 E. isolates.The predominant pathotype isolated was EPEC 19.3% (40/207), followed...

10.3855/jidc.2082 article EN cc-by The Journal of Infection in Developing Countries 2012-08-21

Bacterial adherence determines the virulence of many human-pathogenic bacteria. Experimental approaches elucidating this early infection event in greater detail have been performed using mainly methods cellular microbiology. However, vitro infections cell monolayers reflect vivo situation only partially, and animal models are not available for Therefore, ex human organs might represent an attractive method to overcome these limitations. We infected whole umbilical cords with Bartonella...

10.1128/iai.01502-15 article EN Infection and Immunity 2015-12-29

Introduction: Enterobacteriaceae causing urinary tract infections (UTI) have developed resistance to the commonly used antibiotics due emergence of Extended Spectrum Beta-Lactamases (ESBLs) and Carbapenamase producing Enterobactericeae which are a public health problem worldwide. This study aims determine prevalence characterize ESBLs carbapenamase Enterobactericeae. Method: A cross-sectional was carried out in Gertrude's Children's Hospital, Nairobi. 238 urine samples were collected from...

10.4236/aim.2024.147026 article EN Advances in Microbiology 2024-01-01

Background: Extended spectrum beta lactamases (ESBLs) producing Enterobacteriaceae cause infections that are often reported in both hospital and community setting. These on the increase jeopardize achievement of modern medicine because their clinical implications. There is need for surveillance measures to be taken, by health care personnel at large. Methodology: We examined 330 diarrhea stool samples from children below age 5 years processed them. A total 96 (29%) were identified as...

10.4236/aim.2019.910052 article EN Advances in Microbiology 2019-01-01

Antimicrobial resistance (AMR) is a global threat to public health and particularly children. This study aimed determine the prevalence of multidrug fecal Klebsiella spp on selected beta lactam (3rd generation cephalosporins carbapenems) fluoroquinolone classes drugs in four facilities serving slum communities Nairobi city Kenya. Additionally, genetic basis for observed. A cross sectional laboratory based was undertaken where total 1171 children below 16 years were selected, from whom stool...

10.4236/aim.2021.1110041 article EN Advances in Microbiology 2021-01-01

Background: Urinary tract infection (UTI) is a bacterial affecting males and females but more prevalent in expectant women. ESBLs are bacteria with enzymes that make them resistant to many antibiotics, posing significant health challenge. This study aims determine the characteristics of ESBL-producing causing UTIs Methodology: A self-administered survey was carried out; 300 women were recruited using random sampling method. questionnaire used collect socio-demographic information. Urine...

10.4236/aim.2023.1312037 article EN Advances in Microbiology 2023-01-01

Infections by Streptococcus pneumoniae are among the leading causes of illness and death in children below 5 years, people with underlying debilitating medical conditions, elderly worldwide. Over past three decades, antimicrobial resistance S. has drastically increased, reported Penicillin, erythromycin, trimethoprim/sulfamethoxazole, vancomycin, tetracycline, chloramphenicol ofloxacin. This phenomenon necessitated a continuous search for alternative compounds against pneumoniae, such as...

10.37284/eajhs.7.1.1743 article EN East African Journal of Health and Science 2024-02-10

BACKGROUND Campylobacter spp. are among the global causes of food poisoning and harbour virulence resistance genes which play a role in invasion antibiotic resistance. This study aimed to detect selected archived isolated from children Kibera, Nairobi, Kenya. MATERIALS AND METHODS was retrospective laboratory-based cross-sectional on samples at Department Public Health, Pharmacology Toxicology, University Nairobi. isolates were cultured modified charcoal cefoperazone deoxycholate agar...

10.4314/ajhs.v36i6.2 article EN other-oa African Journal of Health Sciences 2024-10-30
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