A5056402695- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Autoimmune Bullous Skin Diseases
- Genomics, phytochemicals, and oxidative stress
- Metabolism, Diabetes, and Cancer
- Platelet Disorders and Treatments
- Cerebrovascular and genetic disorders
- Drug-Induced Adverse Reactions
- Pharmacovigilance and Adverse Drug Reactions
- Folate and B Vitamins Research
- Erythrocyte Function and Pathophysiology
- Angiogenesis and VEGF in Cancer
- Blood groups and transfusion
- Lipid metabolism and disorders
- Liver Disease and Transplantation
- Linguistic, Cultural, and Literary Studies
Shaoxing People's Hospital
2008-2024
Zhejiang University
2014
China-Japan Friendship Hospital
2007-2009
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2008
We demonstrated first that the nuclear factor erythroid 2-related 2 (Nrf2) activator RTA 408 has a protective effect against diabetic cardiomyopathy. found could stimulate entry of Nrf2 protein, regulate mitochondrial fission-fusion balance, and redistribute p65, which significantly alleviated oxidative stress level in cardiomyocytes, thereby reducing apoptosis inflammation, protecting systolic diastolic functions heart.
The present case-control study explored the interaction between marine-derived n-3 long chain polyunsaturated fatty acids (n-3 LC PUFAs) and uric acid (UA) on glucose metabolism risk of type 2 diabetes mellitus (T2DM). Two hundred eleven healthy subjects in control group 268 T2DM case were included. Plasma phospholipid (PL) biochemical parameters detected by standard methods. PL C22:6n-3 was significantly lower than group, negatively correlated with fasting (r = −0.177, p < 0.001). Higher...
Objective To study the effects of high fat diet on functions islet β cells and role uncoupling protein-2(UCP2)therein possible mechanism.Methods Fonv SD rats were randomly divided into two equal groups:high-fat-(HF)diet group,fed with HF for 20 weeks,and normal control(NC)group,fed diet.At end twentieth week blood samples collected from heart to determine serum fasting glucose(FBG)and insulin(FINS),and plasma nitrotyrosine,malondialdehyde(MDA),and glutamylcysteinylglycine(GSH),indicators...
Objective To investigate characteristics of free fatty acid (FFA) and high-sensitivity C-reactive protein (hs-CRP) in patients with type 2 diabetes mellitus metabolic syndrome (MS) compared to those without MS. Methods Totally 120 who received blood glucose control Shaoxing People's Hospital from January June 2013 were recruited divided into MS group (n=56) non-MS (n=64). The serum FFA profile the was measured by enzymatic assay, hs-CRP level particle-enhanced immuno-precipitation...
Objective To investigate the relationship among magnetic resonance imaging measured area of intra-abdominal fat(MRI-IAF)and serum phospholipids fatty acid composition patients with metabolic syndrome. Methods We compared differences MRI-IAF and polyunsaturated 36 cases syndrome 41 in control group. We also investigated relevance MRI-IAF, waist circumference, body mass index(BMI)and acids syndrome. A stepwise regression analysis was applied to determine which kind can predict fat...
Objective To study the mechanism of ectopically fat deposition in islets high-fat-diet rat models and its relationship with islet beta-cell insulin resistance. Methods Forty healthy male SD rats (weight 160 to 170 g, 8-week old) were randomly assigned (HF) normal diet (NC) groups. Rats HF group (n=20) fed high NC diet. At 20 weeks, fasting blood glucose (FBG), serum (Ins), triglyceride (TG) determined. Glucose infusion rate (GIR) was measured by using euglycemic hyperinsulinemia...
Objective To investigate the relationship between triglyceride and serum polyunsaturated fatty acid (PUFA) in patients with metabolic syndrome (MS).Methods Totally 74 MS (MS group) 62 healthy subjects (normal control group,NC were recruited from June 2011 to 2012 Shaoxing People's Hospital.Serum phospholipid profiles analyzed capillary gas chromatography.Serum lipids measured by enzymatic assay.Results The concentration was significantly higher group than that NC [(2.0 ±0.8) mmol/L vs.(1.3...
To investigate the effect of beta cell lipoapoptosis after long term high-fat feeding in rats, and to relationship between oxidative stress, gene expression lipoapoptosis.Forty-one SD male rats were randomly divided into 2 groups: diet group (HF group) control (NC group). At end 28 weeks, levels malondialdehyde (MDA) glutamylcysteinylglycine (GSH) plasma pancreatic tissue,the early-phase insulin secretion cells, apoptosis (TUNEL technology) uncoupling protein (UCP2) islets measured.The...
The association of the serum phospholipid fatty acid components with high-sensitivity C reactive protein in patients metabolic syndrome and type 2 diabetes mellitus was investigated.Saturated increased (45.98±1.55 vs 42.05±2.04,P＜0.01),while polyunsaturated decreased(42.38±1.93 46.60±2.06,P＜0.01),and high sensitivity significantly increased[(6.36± 1.28 0.79±0.45) mg/L,P＜0.01)]. Key words: Metabolic syndrome; Diabetes mellitus,type 2; Phospholipid acid; High-sensitivity
The association of the serum phospholipid fatty acid components with lipid profiles in patients newly-diagnosed type 2 diabetes mellitus was investigated.Saturated newly diagnosed increased(48.79±1.55 vs 42.58±1.96,P<0.01),whereas monounsaturated and polyunsaturated were decreased(10.72±1.53 12.09±1.32,33.41±2. 16 35.79±2.41.6.08±1.66 9.54±1.54,all P<O.01). Key words: Phospholipid acid; Diabetes mellitus,type 2; Plasma lipids
Objective To study the relationship between NF kappa-B (NF-κB) and development of diabetic macroangiopathy in patients with type 2 diabetes, expression level Nuclear Faetor-κB peripheral mononuclear cell diabetes without were compared, Methods Enzyme-linked immunosorbent assay was used to measure soluble intercellular adhesion molecule-1 (slCAM-1) plasma immunohistochemical method activity NF-κB blood mononu-clear 50 macroangiopathy(G3) , 41 maeroangiopathy(G2) 30 nor-real control...
Objective To investigate the relationship between serum phospholipid polyunsaturated fatty acids (PUFA) and interleukin-6 (IL-6) in patients with metabolic syndrome. Methods Serum PUFA profiles of 61 syndrome 55 healthy controls was analyzed high performance gas chromatography. Enzyme-linked immunosorbent assay used to measure IL-6 levels. Results The concentration significantly higher MS group than control [(16.0±4.7)pg/ml vs. (9.2±2.6)pg/ml, P=0.000]. The total percentage...
Objective To explore the effects of humanized nursing service in ophthalmology ward. Methods Between May 2016 to February 2018, a total 200 patients ward Shaoxing People's Hospital Zhejiang Province were selected as research subjects by convenience sampling method. According sequence admission, divided into control group and intervention group, with 100 cases each group. The both groups received routine ophthalmic care. humanistic at same time. scores Self-rating Anxiety Scale (SAS) ,...