Pleiotropic protective roles of melatonin against aluminium-induced toxicity in rats.

• DOI: 10.4149/gpb_2015028
• Publication Date: 2015-10-01
• Authors: Mohamed Salah All...; Rafik Hachani; Saber Abdelkader ...; Anouer Feriani; Jean Claud Murat; Kamel Kacem; Abdelfatteh El Feki
• Keywords: TBARS

This study aimed to investigate the potential effects of melatonin on aluminium-induced toxicity in a rat model using set biochemical, inflammatory, oxidant, lipid profile criteria and hepatic integrity (verified by hematoxylin-eosin staining). The results indicated that AlCl3 administration during 60 days (100 mg/kg b.w.) significantly increased activities transaminases AST ALT 46% (p < 0.001) 21% 0.01), lactate dehydrogenase (LDH) 30% 0.001), levels bilirubin 85% total cholesterol 115% triglycerides 130% LDL-cholesterol 413% oxidized LDL (oxLDL) 51% 0.01) apolipoprotein B100 (apoB100) 63% as compared controls. inflammatory markers (TNF-α, IL-2, IL-6) were associated higher peroxidation (TBARS) level. Also, both plasma HDL-cholesterol level receptors expression antioxidant protein (SOD, CAT, GPx) are decreased. Those physiological disturbances were, however, noted alleviate following co-administration (10 b.w.). Overall, present is first provide evidence anti-inflammatory, anti-oxidant, anti-lipidic and, hence, therapeutic with regard control prevention aluminium-intoxication.