A5009011930- Renin-Angiotensin System Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Pesticide Exposure and Toxicity
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Cholesterol and Lipid Metabolism
- Protease and Inhibitor Mechanisms
- Vitamin C and Antioxidants Research
- Heavy Metal Exposure and Toxicity
- Hydrogen's biological and therapeutic effects
- Drug-Induced Hepatotoxicity and Protection
- Eicosanoids and Hypertension Pharmacology
- Circadian rhythm and melatonin
- Nitric Oxide and Endothelin Effects
- Animal testing and alternatives
- Antioxidant Activity and Oxidative Stress
- Nigella sativa pharmacological applications
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Cell Adhesion Molecules Research
- Drug Transport and Resistance Mechanisms
- Fatty Acid Research and Health
- Collagen: Extraction and Characterization
University of Carthage
2010-2020
Université Paris Cité
2011-2020
Hôpital Lariboisière
2011-2014
The current study was designed to investigate the possible mechanism involved in hyperglycemia induced by chronic exposure deltamethrin (DLM) rat and assess whether this damage is amenable modulation Zygophyllum album. DLM, a synthetic pyrethroid pesticide, administrated at dose of 4 mg/kg body mass, during 60 days. Compared with control, DLM showed significant increase blood glucose (p ≤ 0.01) glycosylated hemoglobin levels clear decrease insulin total levels. In addition, hepatic glycogen...
This study aimed to investigate the potential effects of melatonin on aluminium-induced toxicity in a rat model using set biochemical, inflammatory, oxidant, lipid profile criteria and hepatic integrity (verified by hematoxylin-eosin staining). The results indicated that AlCl3 administration during 60 days (100 mg/kg b.w.) significantly increased activities transaminases AST ALT 46% (p < 0.001) 21% 0.01), lactate dehydrogenase (LDH) 30% 0.001), levels bilirubin 85% total cholesterol 115%...
This study is the first to examine possible mechanism by which long-term exposure permethrin (PER) can promote arterial retention of proatherogenic lipid and lipoproteins related vascular dysfunction in rats. Experimental animals were administered two doses oral PER, PER-1 (2.5 mg/kg/bw) PER-2 (5 mg/kg/bw), for 90 consecutive days. The results indicated that both increased plasmatic aortic total cholesterol, low-density lipoprotein cholesterol (LDL-C), apo B-100, oxidized LDL together with...
The interactions between the effects of sympathetic nervous system (SNS) and angiotensin II (ANG II) on vascular extracellular matrix (ECM) synthesis were determined in rats. mRNA protein content collagen I, III elastin abdominal aorta (AA) femoral artery (FA) was investigated Wistar–Kyoto rats treated for 5 weeks with guanethidine, a sympathoplegic, losartan, an ANG AT1 receptor (AT1R) blocker, or both. noradrenaline (NE) mRNA, involved, tested cultured smooth muscle cells (VSMCs) vitro....
Pro-inflammatory cytokines regulation by sympathetic nervous system (SNS) and angiotensin II (ANG II) was widely described in cardiovascular system, but the role of such neuro-humoral interaction needs further investigation this context.We tested SNS-ANG on IL-6 TNF-α mRNA expression left ventricle (LV) aorta from normotensive rats sympathectomy with guanethidine blockade ANG AT1 receptors (AT1R) antagonist losartan.mRNA synthesis were performed Q-RT-PCR.In LV, increased 63% (p < 0.01) after...
The aim of our present study is to investigate the interaction between angiotensin II (ANG II) and sympathetic nervous system (SNS) on matrix metalloproteinase MMP-2 MMP-9 expression activity in juvenile rat aorta under normal conditions.Sympathectomy with guanethidine blockade ANG receptors (AT1R) by losartan were performed alone or combination new-born rats.mRNA, protein examined Q-RT-PCR, immunoblotting zymography, respectively.MMP-2 mRNA amount decreased after sympathectomy AT1R an...
The interactions between the sympathetic nervous system (SNS) and angiotensin II (ANG II), their direct effects in vitro on enzymes involved vascular extracellular matrix (ECM) degradation, were examined. Rats treated with guanethidine, losartan or combined treatments. mRNA, protein activity of metalloproteinase (MMP)-2 MMP-9 mRNA tissue plasminogen activator (t-PA) inhibitor 1 (PAI-1) quantified abdominal aorta (AA) femoral artery (FA). Norepinephrine (NE) ANG adrenergic (β, α1 α2)...
Extracellular matrix (ECM) synthesis regulation by sympathetic nervous system (SNS) or angiotensin II (ANG II) was widely reported, but interaction between the two systems on ECM needs further investigation.We tested implication of SNS and ANG in juvenile rat aorta.Sympathectomy with guanethidine (50 mg/kg, subcutaneous) blockade AT1 receptors (AT1R) blocker losartan (20 mg/kg/day drinking water) were performed alone combination rats. mRNA protein collagen elastin examined Q-RT-PCR...