Integrating Genome and Epigenome Data to Identify Tissue-specific DNA Methylation Biomarkers for Cancer Risk

• DOI: 10.5281/zenodo.8226213
• Publication Date: 2023-08-08
• Authors: Yaohua Yang; Yaxin Chen; Shuai Xu; Xingyi Guo; Guochong Jia; Jie Ping; Xiang Shu; Tianying Zhao; Fangcheng Yuan; Gang Wang; Yufang Xie; Hang Ci; Dan Liu; Fei Ye; Xiao‐Ou Shu; Wei Zheng; Qiuyin Cai; Jirong Long
• Keywords: Epigenome; Epigenomics

DNA methylation prediction models for seven tissue types, including breast, colon, kidney, lung, ovary, prostate, and testis. Data from Gene-Tissue Expression (GTEx) consortium were utilized for single- and cross-tissue model development using elastic net and multivariate-response penalized regression, respectively.