A5049259251- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Folate and B Vitamins Research
- Gene expression and cancer classification
- Cancer-related gene regulation
- Cell Image Analysis Techniques
- Microbial Community Ecology and Physiology
- Poverty, Education, and Child Welfare
- Supercapacitor Materials and Fabrication
- Endometriosis Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Adsorption and biosorption for pollutant removal
- Carbon and Quantum Dots Applications
- Educational Reforms and Innovations
Vanderbilt University Medical Center
2023-2024
Vanderbilt University
2023-2024
University of Hawaiʻi at Mānoa
2018-2023
King's College London
2022-2023
University of Hawaii System
2018-2023
Wannan Medical College
2022
University of Hawaii Cancer Center
2020
Lanzhou University
2016
Genome-wide association studies (GWAS) have identified more than 200 breast cancer risk-associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function. In this study, we conducted a proteome-wide study (PWAS) to identify proteins tissue related risk.
This study was designed to identify lncRNA biomarker candidates using lung cancer data from RNA-Seq and microarray platforms separately.Lung datasets were obtained the Gene Expression Omnibus (GEO, n = 287) The Cancer Genome Atlas (TCGA, 216) repositories, only common lncRNAs used. Differentially expressed (DE) in tumors with respect normal selected Affymetrix TCGA datasets. A training model consisting of top 20 DE used for validation Agilent second similar generated dataset.First, a...
Abstract The relationship between tissue-specific DNA methylation and cancer risk remains inadequately elucidated. Leveraging resources from the Genotype-Tissue Expression consortium, here we develop genetic models to predict at CpG sites across genome for seven tissues apply these genome-wide association study data of corresponding cancers, namely breast, colorectal, renal cell, lung, ovarian, prostate, testicular germ cell cancers. At Bonferroni-corrected P < 0.05, identify 4248 CpGs...
Previous studies suggest a potential link between glycosylation and prostate cancer. To better characterize the relationship two, we performed study to comprehensively evaluate associations genetically predicted blood plasma N-glycan levels cancer risk.Using genetic variants associated with as instruments, evaluated of 138 N-glycans risk. We analyzed data 79,194 cases 61,112 controls European ancestry included in consortia BPC3, CAPS, CRUK, PEGASUS, PRACTICAL.We identified three be risk...
We present GranatumX, a next-generation software environment for single-cell RNA sequencing (scRNA-seq) data analysis. GranatumX is inspired by the interactive webtool Granatum. enables biologists to access latest scRNA-seq bioinformatics methods in web-based graphical environment. It also offers developers opportunity rapidly promote their own tools with others customizable pipelines. The architecture of allows easy inclusion plugin modules, named Gboxes, which wrap around written various...
Inequality in education occurs many countries and regions, it has not been addressed strongly effectively. In China, faces challenges, particularly relation to gender inequality. Firstly, the article analyses summarises current state of inequality, pointing out that women China have significantly fewer years than men, contrast between urban rural areas is more pronounced. Secondly, paper will also find lower enrolment rates less access further education, both at compulsory primary level...
Abstract We present GranatumX, a next-generation software environment for single-cell data analysis. GranatumX is inspired by the interactive web tool Granatum. It enables biologists to access latest bioinformatics methods in web-based graphical environment. also offers developers opportunity rapidly promote their own tools with others customizable pipelines. The architecture of allows easy inclusion plugin modules, named Gboxes, that wrap around written various programming languages and on...
Objective. A case-control study was conducted to explore the clinical value of three-dimensional transvaginal ultrasound in diagnosis endometrial receptivity (ER) and ovarian function patients with infertility. Methods. total 308 infertile women treated our hospital from March 2020 June 2021 were enrolled as observation group, another 300 childbearing age who underwent physical examination same period control group. The ER infertility analyzed by comparing classification subendometrial blood...
Abstract The relationship between tissue-specific DNA methylation and cancer risk remains inadequately elucidated. Leveraging the Genotype-Tissue Expression (GTEx) consortium, we developed genetic models to predict at CpG sites (CpGs) across genome for seven tissues applied these genome-wide association study (GWAS) data of corresponding cancers, namely breast, colorectal, renal cell, lung, ovarian, prostate, testicular germ cell cancers. At Bonferroni-corrected P <0.05, identified 2,776...
Abstract Background: Genome-wide association studies (GWAS) have identified over 200 breast cancer risk associated genetic loci, yet the causal genes and biological mechanisms for most loci remain elusive. Proteins, as final gene products, are pivotal in cellular function. In this study, we conducted a proteome-wide study (PWAS) to identify proteins tissue relation risk. Methods: We profiled proteome samples from 120 cancer-free European-ancestry women Susan G. Komen Tissue Bank. Protein...
Abstract Introduction Genome-wide association studies (GWAS) have identified &gt;60 genomic loci for lung cancer risk. However, causal genes and the underlying biological mechanisms most of these remain unknown. Therefore, we conducted a multi-omics study to identify susceptibility genes. Method We first transcriptome-wide (TWAS) using S-PrediXcan framework. Whole transcriptome data from adjacent-normal tissue samples 304 European-ancestry patients were used build genetic prediction...
Abstract Prostate cancer is the second most frequently diagnosed malignancy among males in many countries. There are critical needs to better understand its etiology and identifying effective biomarkers improve early detection. Many proteins modified by glycans that bind proteins, a post-translational modification for normal physiological processes. Studies have linked dysregulation of glycosylation several human diseases including prostate cancer. Multiple glycan alterations been identified...
Abstract Objective: Genome-wide association studies (GWAS) have identified more than 50 loci for lung cancer risk. However, susceptibility genes and the underlying mechanisms these risk remain largely unknown. We conducted a transcriptome-wide study (TWAS) to identify cancer. Methods: Transcriptome data from normal tissue whole-genome sequencing 444 participants of European ancestry in Genotype-Tissue Expression (GTEx, version 8) were used build lung-tissue models predict gene expression...
Objectives: Previous studies have suggested a potential link between glycan levels and pancreatic cancer. To better characterize this relationship, we performed study to evaluate the association genetically predicted N-glycan in plasma cancer risk.Methods: Using genetic variants identified be associated with large genome-wide (GWAS) as instruments, evaluated associations N-glycans risk by analyzing data from 8275 cases 6723 controls.Results: We observed that lower PGP110 were significantly...
Bourdieu's theory of cultural reproduction has significant implications for the study educational inequality between urban and rural China.Firstly, article analyses impact economic capital, which mainly includes an analysis income gap areas leading to different affordability tuition fees, further affects issue enrolment dropout rates in areas.In addition, this section suggests that post-university careers children are limited by family background.Secondly, looks at role capital education,...