A5023239998- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Photoacoustic and Ultrasonic Imaging
- Neural dynamics and brain function
- Atomic and Subatomic Physics Research
- Advanced Fluorescence Microscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Animal Ecology and Behavior Studies
- Species Distribution and Climate Change
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Visual perception and processing mechanisms
Maastricht University
2016-2023
Philips (Netherlands)
2023
Abstract The mesoscopic organization of the human neocortex is great interest for cognitive neuroscience. However, fMRI in humans typically maps functional units processing on a macroscopic level. With advent ultra-high field MRI (≥7T), it has become possible to acquire data with sub-millimetre resolution, enabling probing laminar and columnar circuitry humans. Currently, BOLD responses are not directly observed but inferred via analysis, due coarse spatial resolution (e.g. 0.7–0.8 mm...
Abstract The ability to image human tissue samples in 3D, with both cellular resolution and a large field of view (FOV), can improve fundamental clinical investigations. Here, we demonstrate the feasibility light-sheet imaging ~5 cm 3 sized formalin fixed brain up ~7 paraffin embedded (FFPE) prostate cancer samples, processed FFPE-MASH protocol. We present microscopy prototype, cleared-tissue dual Selective Plane Illumination Microscope (ct-dSPIM), capable fast 3D high-resolution...
Diffusion MRI (dMRI) in ex vivo human brain specimens is an important research tool for neuroanatomical investigations and the validation of dMRI techniques. Many applications have benefited from very high resolutions achievable on small-bore preclinical or animal scanners small tissue samples. However, investigation entire brains post mortem provides context white matter (WM) network systems gray (GM) areas connected through these systems. The intact large bore creates challenges due to...
Several magnetic resonance imaging (MRI) contrasts are sensitive to myelin content in gray matter vivo which has ignited ambitions of MRI-based cortical histology. Ultra-high field (UHF) MRI, at fields 7 T and beyond, is crucial provide the resolution contrast needed sample over depth cortex get closer layer resolved imaging. Ex MRI human post mortem samples an important stepping stone investigate cortex, validate it against histology techniques applied situ same tissue, resolutions...
To design, construct and validate radiofrequency (RF) transmit receive phased array coils for high-resolution visual cortex imaging at 7 Tesla.A 4 channel 16 was constructed on a conformal polycarbonate former. Transmit field efficiency homogeneity were simulated validated, along with the Specific Absorption Rate, using [Formula: see text] mapping techniques electromagnetic simulations. Receiver signal-to-noise ratio (SNR), temporal SNR (tSNR) across EPI time series, g-factors accelerated...
ABSTRACT Motion signals can bias the perceived position of visual stimuli. While apparent a stimulus is biased in direction motion, electro-physiological studies have shown that receptive field (RF) neurons shifted opposite to at least cats and macaque monkeys. In humans, it remains unclear how motion affect population RF (pRF) estimates. We addressed this question using psychophysical measurements functional magnetic resonance imaging (fMRI) 7 Tesla. systematically varied two factors:...
Abstract The ability to image human tissue samples in 3D, with both cellular resolution and a large field of view (FOVs), can improve fundamental clinical investigations. Here, we demonstrate the feasibility light-sheet imaging ∼5 cm 3 sized formalin fixed brain up ∼7 paraffin embedded (FFPE) prostate cancer samples, processed FFPE-MASH protocol. We present microscopy prototype, cleared-tissue dual Selective Plane Illumination Microscope (ct-dSPIM), capable fast, 3D high-resolution...