A5089106839- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Sperm and Testicular Function
- Endometriosis Research and Treatment
- Advanced Fluorescence Microscopy Techniques
- Advanced Neuroimaging Techniques and Applications
- Anatomy and Medical Technology
- Ovarian function and disorders
- Vagus Nerve Stimulation Research
- Innovations in Medical Education
- Problem and Project Based Learning
- Rabbits: Nutrition, Reproduction, Health
- Growth Hormone and Insulin-like Growth Factors
- Pregnancy and preeclampsia studies
- Surgical Simulation and Training
- Bone Tumor Diagnosis and Treatments
- Cell Image Analysis Techniques
- Advanced MRI Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Advanced Electron Microscopy Techniques and Applications
- Pluripotent Stem Cells Research
- Education Methods and Technologies
- Heart Rate Variability and Autonomic Control
- Photoacoustic and Ultrasonic Imaging
Maastricht University
2013-2024
Max Planck Institute for Human Cognitive and Brain Sciences
2022
Leipzig University
2022
RWTH Aachen University
1998-2011
Universitätsklinikum Aachen
2003
Technical University of Munich
2003
Ludwig-Maximilians-Universität München
2003
Bavarian State Research Center for Agriculture
2003
University of Cambridge
1998-2000
Babraham Institute
1998-2000
To get insight in how theoretical knowledge is transformed into clinical skills, important information may arise from mapping the development of anatomical during undergraduate medical curriculum. If we want to gain a better understanding teaching and learning anatomy, it be pertinent move beyond question consider also what, why when anatomy education. A purposive sample 78 students 2nd, 3rd, 4th 6th year PBL curriculum participated 4 focus groups. Each group came together twice, all...
The vagus nerve has gained a role in the treatment of certain diseases by use stimulation (VNS). This study provides detailed morphological information regarding human cervical at level electrode implant.Eleven pairs nerves and four intracranial were analysed computer software. It was found that right an 1.5 times larger effective surface area on average than left [1,089,492 ± 98,337 vs 753,915 102,490 μm(2), respectively, (P < 0.05)] there is broad spreading within individual nerves. At...
We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture human brain, combining histology, immunohistochemistry, 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D each integrate data from approximately 800 microscopy sections per showing neuronal glial cell bodies, nerve fibers, interneuronal populations, as well ultrahigh-field MRI, all coaligned at 200-μm scale to stacked blockface images obtained during sectioning....
Insulin as well insulin-like growth factor-I (IGF-I) promote early embryo development, and IGF-I binds to the coats of preimplantation rabbit embryos. As receptor is expressed from morula stage onwards, embryos are capable responding insulin IGF-I, which present in oviductal uterine secretions that surround them. The embryonic were removed exclude any influence by bound coats. vitro development such under classical conditions appears be retarded. Addition (68 pM-6.8 nM) or nM-6.8 μM),...
Abstract The ability to image human tissue samples in 3D, with both cellular resolution and a large field of view (FOV), can improve fundamental clinical investigations. Here, we demonstrate the feasibility light-sheet imaging ~5 cm 3 sized formalin fixed brain up ~7 paraffin embedded (FFPE) prostate cancer samples, processed FFPE-MASH protocol. We present microscopy prototype, cleared-tissue dual Selective Plane Illumination Microscope (ct-dSPIM), capable fast 3D high-resolution...
Lumbosacral radicular syndrome (LRS) is probably the most frequent neuropathic pain syndrome. Three months to 1 year after onset, 30% of patients still experience ongoing pain. The management those complex, and treatment success rates are rather low. beneficial effect pulsed radiofrequency (PRF) therapy has been described for LRS in case reports retrospective prospective studies. Up until now, no neurological complications have reported PRF treatment. current clinical audit performed assess...
The spleen is hypothesized to play a role in the autonomic nervous system (ANS)-mediated control of host defence, but neuroanatomical evidence for this assumption rests on sparse number studies, which mutually disagree with respect existence cholinergic or vagal innervation. We conducted an immuno- and enzyme-histochemical study innervation human using complete hilum-embedding approach ensure that only nerves entered left were studied, all splenic included sampled area. Furthermore, embedded...
Introduction: The subthalamic nucleus, substantia nigra, and globus pallidus, three nuclei of the human basal ganglia, play an important role in motor, associative, limbic processing. network ganglia is generally characterized by a direct, indirect, hyperdirect pathway. This study aims to investigate mesoscopic nature these connections between pallidus their surrounding structures. Methods: A post mortem brain specimen including was scanned on 7 T MRI scanner. High resolution diffusion...
Abstract Optical clearing techniques and light sheet microscopy have transformed fluorescent imaging of rodent brains, provided a crucial alternative to traditional confocal or bright field for thin sections. However, labeling human brain tissue through all cortical layers significant portions area, has so far remained extremely challenging, especially formalin fixed adult tissue. Here, we present MASH (Multiscale Architectonic Staining Human cortex): simple, fast low-cost cytoarchitectonic...
Post mortem magnetic resonance imaging (MRI) studies on the human brain are of great interest for validation in vivo MRI. It facilitates a link between functional and anatomical information available from MRI neuroanatomical knowledge histology/immunocytochemistry. However, linking post to microscopy techniques poses substantial challenges. Fixation artifacts tissue deformation extracted brains, as well co registration 2D histology 3D volumes complicate direct comparison modalities....
One of the major, progesterone-dependent proteins secreted into uterine lumen mare is a 19-kDa lipocalin (P19). It associates strongly with embryonic capsule that envelops young horse conceptus in early gestation, suggesting it may be involved sustaining development. However, was not known whether protein transported through and/or trophoblast layer and yolk sac cavity. To address this question, polyclonal antisera were raised against C-terminal peptide (based on deduced amino acid sequence...
Communicating fibres between the phrenic nerve and sympathetic nervous system may exist, but have not been characterized histologically immunohistochemically, even though increased activity due to stimulation for central sleep apnoea entail morbidity mortality. We, therefore, conducted a histological study of establish presence catecholaminergic throughout their course. The entire nerves 35 formalin-fixed human cadavers were analysed morphometrically immunohistochemically. Furthermore, right...
NEURORADIOLOGYT he loss of the radiologic swallow tail sign on MRI scans substantia nigra is a promising diagnostic marker Parkinson disease (1), although its anatomic underpinning unclear.An early influential study showed that hyperintense inner part T2*-weighted images (STh) corresponds to iron-poor areas in and suggested it equal nigrosome 1, dopaminergic region affected earliest strongest (2).This would render STh cellularly specific (2).However, recent postmortem tissue studies have...
Insulin-like growth factor-I (IGF-I) promotes early embryonic development in several species. In the rabbit, IGF-I binds to coats from Day 3 of onward by a 38-kDa protein that is probably insulin-like factor-binding (IGFBP3). present study, ligand, Western, and Northern blot analyses were used demonstrate presence IGF-I-binding activity, immunoreactive IGFBP3 proteins, mRNA horse conceptuses with particularly large amounts conceptus capsule. addition, immunoprecipitation radiolabeled...