A5043713730- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Ethics in Clinical Research
- Reproductive tract infections research
- Global Public Health Policies and Epidemiology
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Blood Pressure and Hypertension Studies
- COVID-19 epidemiological studies
- Sex work and related issues
- Syphilis Diagnosis and Treatment
- COVID-19 Pandemic Impacts
- Reproductive Health and Contraception
- Food Security and Health in Diverse Populations
- Obesity, Physical Activity, Diet
- Health Policy Implementation Science
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Poverty, Education, and Child Welfare
- HIV-related health complications and treatments
- Biomedical Ethics and Regulation
- Herpesvirus Infections and Treatments
University of KwaZulu-Natal
2023-2025
Lux Research (United States)
2024
South African Medical Research Council
2010-2023
Aurum Institute
2020-2022
Sexually transmitted infections (STIs) contribute largely to the burden of health in South Africa and are recognized as major contributors human immunodeficiency virus (HIV) epidemic. Young women particularly vulnerable STIs. The purpose this secondary analysis was examine risk factors associated with prevalent incident STIs among who had participated three clinical trials.A total 5,748 were screened 2293 sexually active, HIV negative, non-pregnant enrolled trials Kwazulu-Natal, Africa....
In VOICE, a phase IIB trial of daily oral and vaginal tenofovir for HIV prevention, at least 50% women receiving active products had undetectable in all plasma samples tested. MTN-003D, an ancillary study using in-depth interviews (IDIs) focus group discussions (FGDs), together with retrospective disclosure pharmacokinetic results, explored adherence challenges during VOICE.We systematically recruited participants data (median six samples), categorized as low (0%, N = 79), inconsistent...
MTN-020/ASPIRE trial and IPM-027/Ring Study recently proved the dapivirine vaginal ring was safe effective with consistent use. To optimize ring's impact, barriers facilitators to adherence must be understood addressed.
South Africa, with its scientific capacity, good infrastructure and high HIV incidence rates, is ideally positioned to conduct large-scale prevention trials. The Prevention Research Unit of the African Medical Council conducted four phase III one IIb trials women-initiated options in KwaZulu-Natal between 2003 2009. A total 7046 women participated, prevalence 25% 45% ranging from 4.5-9.1% per year. Unfortunately none interventions tested had any impact on reducing risk acquisition; however,...
Abstract Background The Pox-Protein Public-Private Partnership is performing a suite of trials to evaluate the bivalent subtype C envelope protein (TV1.C and 1086.C glycoprotein 120) vaccine in context different adjuvants priming agents for human immunodeficiency virus (HIV) type 1 (HIV-1) prevention. Methods In HIV Vaccine Trials Network 111 trial, we compared safety immunogenicity DNA prime followed by DNA/protein boost with coadministration injected intramuscularly via either...
Despite efforts to control the spread of sexually transmitted infections (STIs), these are still highly prevalent in developing world, especially Africa where prevalence and incidence Human immunodeficiency virus (HIV) is also very high. Unfortunately, women bear disproportionate burden both STIs HIV this region. Early diagnosis, treatment prevention therefore crucial population given strong evidence that some have been shown facilitate transmission HIV. This review summarizes epidemiology,...
Introduction Women in sub-Saharan Africa are a priority population for evaluation of new biomedical HIV-1 prevention strategies. Antiretroviral pre-exposure prophylaxis is promising approach; however, clinical trials among young women using daily or coitally-dependent products have found low adherence. Antiretroviral-containing vaginal microbicide rings, which release medication over month longer, may reduce these adherence challenges. Methods ASPIRE (A Study to Prevent Infection with Ring...
Abstract More than 140 million children under five suffered from stunting in 2020. This highlights the ongoing challenge of addressing childhood malnutrition globally. We utilized data a nationally representative sample years age (n = 14,151) who participated cycles South African National Income Dynamics Study (SA-NIDS) (2008–2017). estimated proportion stunted attributed to mothers’ anthropometric characteristics and socioeconomic conditions. also quantified population-level burden...
ABSTRACT Aim To identify the correlates of stunting and investigate their population‐level impacts among children under 5 years in sub‐Saharan Africa. Methods Data from 179 572 five were included nationally representative surveys conducted across 24 African countries (2015–2022). Multivariable logistic regression models risk factors estimated to highlight contributions prevalence study regions. Results Stunting ranged 18% 54%, with rates exceeding 50% Burundi. Lack basic household amenities...
In addition to being the epicentre of HIV epidemic, South Africa also has highest burden sexually transmitted infections (STIs) in world. Therefore, understanding most influential risk factors STIs is a research priority. Using data from 9948 women who resided KwaZulu Natal, Africa, we estimated population attributable quantify combined impacts on STI diagnosis. Overall prevalence was 20%, and incidence 15 per 100 person-years. Four factors: age at sexual debut, single/not cohabiting, two or...
Trichomonas vaginalis is known to be the most common, curable, sexually transmitted infection among active women and may associated with acquisition transmission of HIV. The purpose this analysis determine prevalence incidence T assess risk factors in a cohort participating clinical trial.We analysed data from phase III vaginal diaphragm trial conducted two communities Durban, South Africa 2003 2006. A total 3492 were screened 1485 meeting respective study eligibility criteria enrolled. was...
There continues to be a need for HIV prevention options that women can initiate and use autonomously. The dapivirine vaginal ring (VR) has been shown have favorable safety profile reduce the risk of HIV-1 acquisition. We report on women's experiences with VR adherence during MTN-025/HIV Open-label Prevention Extension (HOPE) study responses Residual Drug Level (RDL) results.
Background DNA plasmids promise a pragmatic alternative to viral vectors for prime-boost HIV-1 vaccines. We evaluated plasmid versus canarypox virus (ALVAC) primes in 2 randomized, double-blind, placebo-controlled trials southern Africa with harmonized trial designs. HIV Vaccine Trials Network (HVTN) 111 tested prime by needle or needleless injection device (Biojector) and plus gp120 protein MF59 adjuvant boost. HVTN 100 ALVAC boost (same protein/adjuvant as 111) needle. Methods findings The...
This article describes the influence of a peer education programme on skills development among 22 women participating in HIV prevention trials. Interviews were used to collect data educator experiences and their opinions trainings. The training enhanced agency confidence engage family community health promotion, including research procedures, thus improving self-esteem communication skills. Training partnering with clinical trial participants as educators is an effective sustainable...
Background Unplanned pregnancy rates in South Africa are high. Effective use of contraception is therefore an essential public health intervention to prevent unplanned pregnancies. This study describes and its impact on women participating HIV prevention research implications for practice. Method A secondary analysis sociodemographic, behavioural, use, incidence data was conducted amongst the Microbicides Development Programme (MDP) 301 trial Durban, Africa. Log-rank tests were carried out...